Chang-e Zhu, Bo Yu, Wen Zhang , Wen-hua Chen, Qi Qi, Yun Miao
Shanghai First People’s Hospital, Shanghai Jiao Tong University, 200080 Shanghai, China
DOI: 10.2340/16501977-2179

Objective: To evaluate the effectiveness and safety of transcranial direct current stimulation for fibro-myalgia.
Methods: Databases, conference records and registered trials were searched for articles published from the date of establishment of the database
through to October 2015. Six randomized controlled trials (n=192) of transcranial direct current stimulation for fibromyalgia were included in the current study.
Data extraction: Two researchers independently screened the literature, assessed methodological quality using the Cochrane Collaboration’s tool, and extracted data.
Data synthesis: Studies were divided into 3 groups for meta-analysis according to stimulation site and polarity. Significant improvement in pain and general fibromyalgia-related function was seen with anodal transcranial direct current stimulation over the primary motor cortex (p<0. 05). However, the pressure pain threshold did not improve (p>0. 05). Anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex did not significantly reduce pain or improve general fibromyalgia-related function compared with sham stimulation (p>0. 05). Cathodal transcranial direct current stimulation over the primary motor cortex did not improve the pressure pain threshold compared with sham stimulation (p>0. 05). No significant adverse effects were seen.
Conclusion: Anodal transcranial direct current stimulation over the primary motor cortex is more likely than sham transcranial direct current stimulation to relieve pain and improve general fibromyalgia-related function.

Appendix S1