Effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention
Zheng Huan, Luo Ming, Shen Yi, Ma Yuan, Kang Wenhui
DOI: 10.2340/16501977-0254
Abstract
Objective: To study the effects of 6 months exercise training on ventricular remodelling and autonomic tone in patients with acute myocardial infarction and percutaneous coronary intervention.
Design: Single-blinded randomized control trial. Participants: Sixty patients with acute myocardial infarction who had undergone percutaneous coronary intervention.
Methods: The exercise group followed a 6-month supervised exercise programme, while the control group received routine recommendations. All patients underwent an incremental cardiopulmonary exercise test and Doppler echocardio-graphy at baseline and after 6 months.
Results: Three patients in the exercise group did not complete the programme. At 6 months follow-up, an improvement was seen in the exercise group compared with the control group regarding peak VO2 (p<0. 01), Powermax (p<0. 05), VO2 at anaerobic threshold (p<0. 01), time to reach anaerobic threshold (p<0. 05), heart rate recovery (p<0. 01), left ventricular end-diastolic diameter (p<0. 01) and left ventricular ejection fraction (p<0. 05).
Conclusion: Six months exercise training in patients with acute myocardial infarction and percutaneous coronary intervention with mild ventricular systolic dysfunction could prevent ventricular remodelling to a certain extent, and favourable modulating sympatho-vagal balance may be an important mechanism.
Lay Abstract
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