Content » Vol 42, Issue 8

Original report

Evidence of reduced sympatho-adrenal and hypothalamic–pituitary activity during static muscular work in patients with fibromyalgia

Diana Kadetoff, Eva Kosek
DOI: 10.2340/16501977-0597


Objective: To assess activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenocortical axis during static exercise in patients with fibromyalgia.
Patients and methods: Sixteen patients with fibromyalgia and 16 healthy controls performed a static knee extension until exhaustion. Plasma catecholamines, adrenocorticotropic hormone and cortisol, as well as blood pressure and heart rate, were assessed before, during and following contraction. Plasma C reactive protein was analysed at baseline.
Results: Blood pressure and heart rate increased during contraction (p < 0. 001) and decreased following contraction (p < 0. 001) in both groups alike. Compared with baseline, plasma catecholamines increased during contraction in both groups (p < 0. 001), but patients with fibromyalgia had lower levels of plasma adrenaline (p < 0. 04) and noradrenaline (p < 0. 08) at all times. Adrenocorticotropic hormone increased at exhaustion in controls (p < 0. 001), but not in patients with fibromyalgia, who also had lower adrenocorticotropic hormone at exhaustion (p < 0. 02) compared with controls. There were no group differences, or changes over time in plasma cortisol. High sensitivity C reactive protein was higher in patients with fibromyalgia compared with controls (p < 0. 02).
Conclusion: Patients with fibromyalgia exhibited a hypoactive sympatho-adrenal system as well as a hypo-reactive hypothalamic-pituitary axis during static exercise.

Lay Abstract


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