Content - Volume 69, Issue

Two different rating scales--a visual analogue scale (VAS) connected to a chart-recorder, and Pain-Track, a micro-computerized system with a 7-step-graded, fixed-point, non-verbal scale (FPNVS)--were evaluated for their capacity to assess experimental, histamine-induced itch continuously in 38 healthy subjects. The consequences for itch perception of using different injection sequences of various ...

The possibility that topically-applied minoxidil might affect the growth cycle of hair follicles was studied in inbred Herston white mice and HRA/Skh1 hairless mice. In the normal follicular cycle, the anagen or growth phase can be followed by autoradiographic demonstration of [3H]thymidine uptake in proliferating matrical cells, and the catagen or regression phase can be recognised, using light m ...

Biopsies from lesional and unaffected skin of 6 patients with psoriasis, taken before and during treatment with psoralen plus UVA (PUVA) were examined immunohistologically, using partially purified polyclonal antibodies to crude supernatants of activated human blood monocytes. By absorption with recombinant derived human monokines, we were able to demonstrate that interleukin-6 (IL-6) (but not IL- ...

Epidermal Langerhans´ cells (LC) were studied in patients with chronic eczematous dermatitis of the palms. The monoclonal antibodies anti-Leu 6 and anti-HLA-DR were used, and the cells visualized with an immunoperoxidase technique. Increased numbers of LC were found in allergic contact dermatitis as well as in irritant contact dermatitis and hyperkeratotic dermatitis of the palms. The increased n ...

A case of the disseminated variant of pagetoid reticulosis is described which progressed after many years of disease to a large cell anaplastic (Ki-1) lymphoma of T-cell type. The lymphoma cells showed abnormal cellular DNA and a high proliferative rate, as revealed by immunophenotypic examination and single-cell DNA measurements. The cells were positive for activation associated antigens and expr ...

A 42-year-old man presented with systemic lupus erythematosus, universal alopecia and non-pruritic hyperpigmented papular mucinosis. The latter was most evident on acral areas. In hyperpigmented areas of the face the immunofluorescence showed deposits as in LE and with alcian blue and colloidal iron an abundance of mucin was demonstrated in the dermis. A lesion on the back showed only papular muci ...

A 50-year-old man was admitted to the hospital with a diagnosis of eczema. Using study of T-cell receptor gene rearrangement on skin biopsies, a diagnosis of mycosis fungoides was made, then confirmed by evolution. This observation provides the opportunity to discuss the usefulness of molecular biology for the early diagnosis of mycosis fungoides.

We collected a 5-year series of drug eruptions. There were 225 cases, 128 of them verified by a positive provocation test. The most common types of clinical reaction were fixed drug eruptions, exanthematous eruptions and urticarias. The drugs most often responsible for the eruptions were antimicrobial agents and antipyretic/anti-inflammatory analgesics. Comparing this series with our three previou ...

Different types of hand eczema in an industrial city were studied. Questionnaires were sent to 20,000 individuals aged 20-65 years, randomly selected from the population register of the city. Those subjects (1,385) considering themselves to have had hand eczema within the previous 12 months were invited to a dermatological examination. It was found that hand eczema occurred twice as often among fe ...

Mole counts were studied in relation to skin complexion in various racial groups. White children had a median total number of naevocytic naevi of 17.0, versus 2.5 in non-white children (p less than 0.001). Young white adults showed a similar mole proneness to that of coloured subjects (61.0 versus 16.0; p less than 0.001). With regard to moles greater than 2 mm diameter in the young-adult group, w ...

In order to ascertain the extent to which the pigmentary system plays a protective role in dithranol-induced irritancy, a within-subject comparison was carried out between normally pigmented and depigmented skin of patients with vitiligo. In open patch tests, various concentrations of dithranol in a cream base were applied to the normally pigmented and depigmented skin of 6 patients with vitiligo. ...

Two cases of melanocytic lesion occurring in condylomata acuminata are described. In situ hybridization with human papillomavirus (HPV) DNA probes specific for 6b, 11, 16, 18 revealed positivity with HPV6 and 11, in the non-dysplastic condylomata, and HPV 18 positivity in the case showing severe dysplasia. The HPV localization was confined to the superficial parakeratotic zones, remote from the me ...

Serum aminoterminal propeptide of type III procollagen (PIIINP) was studied in 73 psoriatics receiving methotrexate and in 11 selected for trial with methotrexate or etretinate. 72 of the patients on methotrexate were also investigated with liver biopsies. The highest PIIINP value was found in a patient with ascites and her PIIINP decreased after medication was discontinued. Psoriatics with fibros ...

A 72-year-old immunocompromised man with myelodysplastic syndrome who developed multiple erythematous, scaly abscesses like lesions on his left foot and lower leg is described. He also had dry scaly lesions on his soles and lesions on several toe nails. A punch biopsy showed abscesses with fungal elements and Trichophyton rubrum was cultured from skin scales and the biopsy. A diagnosis of T. rubru ...

A spore suspension from a granular strain of Trichophyton mentagrophytes under occlusion for 4 days was used to produce two fungal lesions on the upper arm of the Trichophytin-negative author. The material for culture was obtained by stripping across the visible lesions and several centimetres into the surrounding skin. Already when the occlusion was removed, the whole stratum corneum was heavily ...

We used the model of human skin graft on nude mouse to investigate a possible influence of systemically administered cyclosporin A (CsA) on epidermal Langerhans´ cells (LC). This experimental model has the advantage of being independent of the systemic humoral and cellular influences of a human host. No change in the human LC distribution or number could be observed after 3 weeks of CsA therapy a ...

We conducted a trial of topical application of 10% cyclosporin A in an oil preparation in 10 patients with alopecia areata and alopecia universalis. After 12 months of therapy, no beneficial response was observed in any of the 10 patients.

Ten nickel-allergic patients and 5 healthy control subjects participated in a study of the kinetics of the flux and concentration of migrated leukocytes and extracellular PGE1 and PGF2 alpha during a 48 h period, using a skin chamber technique. The patients were provided with two skin chambers, one with and one without nickel challenge. A higher flux of leukocytes, PGE1 and PGF2 alpha was observed ...

Five patients with cerebrovascular hemiplegia developed an endogenous eczema (nummular eczema, pompholyx, allergids, atopic dermatitis). In all cases the dermatitis was mainly confined to the healthy side.

An unusual localization of lichen amyloidosus in a patient with IgG k benign monoclonal gammopathy is reported. After topical treatment with dimethylsulfoxide the lesions improved, but histological examination still showed amyloid deposits.

A study of all new dermatitic out patients greater than 70 years of age, referred in the period January-June 1987 (257 patients), was undertaken to obtain information on the types of skin diseases and the dermatological outpatient services required in the case of the elderly. The group accounted for 14% of all new patients. The leading diagnoses were seborrheic keratosis (15.6%), basal cell carcin ...

A patient with stable chronic myelomonocytic leukaemia was treated with 8-methoxypsoralen photochemotherapy (PUVA) for erythrodermic psoriasis. After 4 months, transformation to acute myeloid leukaemia (AML) occurred. We would suggest caution when considering PUVA therapy in patients with pre-leukaemic disorders.

Monoamine- and diamine oxidase activities were measured by a sensitive photometric assay in 25 psoriasis vulgaris patients. Results were compared with plasma histamine values determined fluorimetrically. Increased plasma histamine levels were associated with significantly lowered diamine--and type B monoamine oxidase activities in platelet-rich plasma of the psoriasis patients. Our data suggest th ...

Psoriasis may improve during dietary supplementation with fish oil containing n-3 fatty acids including eicosapentaenoic acid. In the present study 17 psoriatic patients were treated with Super Gamma-Oil Marine containing a combination of n-3 and n-6 fatty acids (linoleic acid and gammalinolenic acid). After 4 months, excellent improvement was observed in 2 patients, moderate improvement in 8, mil ...

The case is presented of a 32-year-old man with multiple reddish-blue papules on both thighs and sporadic on the lower part of the trunk and lower legs, clinically compatible with multiple ´insect´ bites. The lesions were found to be multiple bites from larvae of the tick Ixodes ricinus. The larvae are about 1 mm long, live very close to the ground, and mainly parasitize small rodents. They are, ...

A study was made of effects of two antihistamines, terfenadine (60 mg twice daily) and astemizole (10 mg once daily) on wheals induced by histamine dihydrochloride (10 mg/ml) in the prick test on the upper back of 15 healthy students. The suppressive effects of terfenadine on the histamine wheal appeared earlier (2 h), and disappeared earlier (within 1 day) than those of astemizole (3 days and 28 ...

No abstract available.

No abstract available.

No abstract available.