WCI Abstract 2017

9th World Congress on Itch (WCI)
October 15-17, 2017, Wrocław, Poland

Abstract Details

Sunday, October 15, 2017


1:30-3:30 PM

IFSI Board meeting

5:00-5:20 PM


5:00-5:10 PM

Opening remarks

Jacek C. Szepietowski (Poland)

5:10-5:20 PM

Opening remarks

IFSI: A successful society for the future

Earl Carstens (USA)

5:20-7:00 PM

Plenary Session

Chairs: Earl Carstens (USA); Elke Weisshaar (Germany)

5:20-5:50 PM

Bernhard Lecture

Itchy dermatoses in the collection of Wroclaw moulages

Jacek C. Szepietowski (Poland)


5:50-6:20 PM

Kuraishi Lecture 

Specificity or pattern: implications for clinical itch

Martin Schmelz (Germany)


6:20-6:50 PM

Neisser Lecture

Itch and psyche

Mohammad Jafferany (USA)


Monday, October 16, 2017 AM

8:30-9:00 AM

Morning session

Hot off the bench: Latest news by young investigators

Chairs: Hermann Handwerker (Germany); Adam Reich (Poland)

8:30-8:40 AM

The regulation of pruritus in psoriasis and atopic dermatitis – a possible role for CD26/DPPIV

Eriko Komiya-Suyama (Japan), Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Yasushi Suga, Utako Kimura, Taketo Yamada, Mitsutoshi Tominaga, Kenji Takamori, Kei Ohnuma, Chikao Morimoto


8:40-8:50 AM

Chronic itch in hemodialysis patients: A follow-up study of GEHIS (German Epidemiological Hemodialysis-Itch Study)

Natalie Plewig (Germany), Robert Ofenloch, Thomas Mettang, Elke Weisshaar


8:50-9:00 AM

Attentional bias to itch-related images in a clinical itch population

Michellie Young (UK), Melanie Burke, Donna Lloyd


9:05-10:30 AM

Plenary Session

Neurobiology of Itch

Chairs: Martin Steinhoff (Ireland); Matthias Ringkamp (USA);

9:05-09:25 AM

Effects of pruritogens and algogens on rostral ventromedial medullary (RVM) ON and OFF cells

T. Follansbee, Iodi Carstens (USA), Earl Carstens, T. Akiyama, M. Fujii, A. Davoodi, M. Nagamine


9:25-09:45 AM

How scratching can take its “Toll” on itch, new insights into innate immune mechanisms of peripheral itch sensitisation

Ian McDonald (Ireland), Attila Szöllősi, Imre Szabó Lőrinc, Martin Steinhoff


9:45-10:00 AM

Preferential activation of subtypes of polymodal nociceptive C-fibers in pigtail monkey following intradermal injection of β-alanine and bovine medullary protein 8-22

Amanda H Klein, Timothy V Hartke, Matthew Wooten, Gang Wu, Matthias Ringkamp (USA)


10:00-10:15 AM

Itch as a basic constituent of somatosensation: Evidence for multi-modal capacity of primary C-afferents

Behrang Sharif (Canada), Ariel Ase, Alfredo Ribeiro da Silva, Philippe Séguéla


10:15-10:30 AM

Sulfated CCK8 induces alloknesis via spinal CCK2 receptor in mice

Mitsutoshi Tominaga (Japan), Fumiya Kusube, Kotaro Honda, Nobuaki Takahashi, Hisashi Naito, Fumiyuki Yamakura, Yasushi Suga, Yasuhiro Tomooka, Kenji Takamori


11:00 AM-12:30 PM

Concurrent I

Special Interest Groups (SIGs)

Chairs: Thomas Mettang (Germany); Jacek C. Szepietowski (Poland)

11:00-11:15 AM

SIG Sensitive Skin

Laurent Misery (France), Sonja Ständer, Jacek C. Szepietowski, Adam Reich, Joanna Wallengren, Andrea W.M. Evers, Kenji Takamori, Emilie Brenaut, Christelle Le Gal-Ianotto, Joachim Fluhr, Enzo Berardesca, Elke Weisshaar


11:15-11:30 AM

SIG Scoring itch in clinical trials

Sonja Ständer (Germany), Matthias Augustin, Jacek C. Szepietowski


11:30-11:45 AM

SIG Questionnaires

Elke Weisshaar (Germany), Jörg Kupfer, Antoinette van Laarhoven, Uwe Gieler, Masutaka Furue, Hidehisa Saeki, Andrea Evers, Gil Yosipovitch


11:45 AM-12:00 PM

SIG Paraneoplastic itch

Elke Weisshaar (Germany), Thomas Mettang, Sonja Ständer, Frank Brennan, Hong Liang Tey, Gil Yosipovitch


12:00-12:15 PM

SIG Uremic itch

Thomas Mettang (Germany), Jacek C. Szepietowski, Laurent Misery, Elke Weisshaar


12:15-12:30 PM


11:00 AM-12:30 PM

Concurrent II

Skin, inflammation and itch

Chairs: Brian Kim (USA); Laurent Misery (France)

11:00-11:15 AM

New insights into the pathophysiology of itch during ciguatera fish poisoning

Killian L’Herondelle (France), Laurent Misery, Christelle Le Gall-Ianotto, Réginald Philippe, Matthieu Talagas, Olivier Mignen, Richard Lewis, Raphaele Le Garrec


11:15-11:30 AM

Intra- and extra-lesional sensitization for non-histaminergic and mechanically-evoked itch in atopic dermatitis

Hjalte Holm Andersen (Denmark), Jesper Elberling, Henrik Sølvsten, Gil Yosipovitch, Lars Arendt-Nielsen


11:30-11:45 AM

Attenuated activation of endogenous glucocorticoids in keratinocytes induces alloknesis in atopic dermatitis via aberrant artemin production

Akira Matsumoto (Japan), Hiroyuki Murota, Mika Terao, Ichiro Katayama


11:45 AM-12:00 PM

Neutrophil-somatosensory neuron crosstalk drives acute and chronic itch

Carolyn Walsh (USA), Jamie Schwendinger-Schreck, Jacques Deguine, Emily Brock, Rose Hill, Jessica Wei, Natalie Kelava Kucirek, Karsten Gronert, Greg Barton, Diana Bautista


12:00-12:15 PM

Cutaneous 4-1BB/4-1BBL signaling induces severe skin inflammation and chronic itch

Stefan Tran, Verena Kupas, Kristian Holz, Marcus Maurer, Thomas A. Luger, Sonja Ständer, Karin Loser (Germany)


12:15-12:30 PM

Sema3A expression is regulated by calcium/PKC/MAPK/AP-1 signaling axis in normal human epidermal keratinocytes

Yayoi Kamata (Japan), Yoshie Umehara, Azumi Sakaguchi, Yasushi Suga, Mitsutoshi Tominaga, Kenji Takamori


12:30-2:00 PM

Lunch and poster viewing I

Chairs: Elke Weisshaar (Germany), Gil Yosipovitch (USA)

2:00-3:30 PM

Plenary session

New antipruritic treatments

Chairs: Sonja Ständer (Germany); Alan Fleischer (USA)

2:00-2:15 PM

Randomized, double-blind, placebo-controlled phase 2 clinical trial of serlopitant effects on multiple measures of pruritus in patients with prurigo nodularis

Sonja Ständer (Germany), Paul Kwon, Thomas A. Luger


2:15-2:30 PM

Serlopitant for treatment of chronic pruritus: results of a randomized, multicenter, double-blind, placebo-controlled phase 2 clinical trial

Gil Yospovitch (USA), Sonja Ständer, Matthew B. Kerby, James W. Larrick, Andrew J. Perlman, Edward F. Schnipper, Xiaoming Zhang, Jean Y. Tang, Thomas A. Luger, Martin Steinhoff


2:30-2:45 PM

Recovery of peptidergic epidermal nerve fiber density by Tofacitinib in a mouse model of atopic dermatitis

Kristen Sanders (USA), Kento Sakai, Gil Yosipovitch, Tasuku Akiyama


2:45-3:00 PM

Crisaborole ointment provides early relief of pruritus in two phase 3 clinical trials in patients with mild or moderate atopic dermatitis

Emma Guttman-Yasky, Gil Yosipovitch (USA), Dedee Murrell, Jon Hanifin


3:00-3:10 PM

New insights into the anti-pruritic activity of the neurokinin-1 antagonist Aprepitant: partial activation of EGFR signaling in human keratinocytes as a mechanism for reducing erlotinib induced-pruritus

Shawn Kwatra (USA), Cory Nanni, Yevgeniy Semenov, Callie Roberts, Madison Krischak, Madan Kwatra


3:10-3:20 PM

Efficacy of systemic treatments of psoriasis on pruritus: A systemic literature review and meta-analysis

Emilie Brenaut (France), Chloé Théréné, Thomas Barnetsche, Laurent Misery


3:20-3:30 PM

Randomized, double-blind, placebo-controlled study of monoclonal anti-IgE antibody omalizumab in the management of pruritus in chronic spontaneous urticaria in the pediatric population.

Barnali Mitra (India), Biju Vasudevan, Reema Solanki, Debdeep Mitra


4.00-5.30 PM

Concurrent I

Methods in itch research (clinical)

Chairs: Andrea Evers (The Netherlands); Jörg Kupfer (Germany)

4.00-4.20 PM

How to alter placebo and nocebo effects in patients with chronic itch?

Andrea Evers (The Netherlands)


4.20-4.40 PM

Methods in itch research: Arguments to improve standardization of research methods.

Joerg Kupfer (Germany), Uwe Gieler, Stephanie Kiupel, Christina Schut


4.40-4.55 PM

Measuring pediatric itch severity: Does personal experience with chronic pruritus influence parent’s ability to be proxies?

Grace Lee, Sandy François, Shelby Smith, Caitlin Haydek, James Roberts, Kuang-Ho Chen, Suephy Chen (USA)


4.55-5.10 PM

Validation of the peak pruritus numerical rating scale: results from clinical studies of dupilumab in adult patients with moderate-to-severe atopic dermatitis

Gil Yosipovitch (USA), Matthew Reaney, Laurent Eckert, Lauren Nelson, Marci Clark, Marius Ardeleanu, Allen Radin, Abhijit Gadkari


5.10-5.20 PM

12-Item Pruritus Severity Scale: development and validation of new itch severity questionnaire

Adam Reich (Poland), Agnieszka Bożek, Katarzyna Janiszewska, Jacek C. Szepietowski


5.20-5.30 PM

Clinical bandings of Patient-Oriented Eczema Measure (POEM) scores among Japanese atopic dermatitis patients

Makiko Kido-Nakahara (Japan), Yumi Yasukochi, Takeshi Nakahara, Rie Kuroki, Tetsuya Koga, Toshihiko Mashino, Yuichi Kurihara, Masutaka Furue


4.00-5.00 PM

Concurrent II

Methods in itch research (experimental)

Chairs: Glenn Giesler (USA); Roman Rukwied (Germany)

4.00-4.15 PM

Methods in experimental itch research – an introduction

Roman Rukwied (Germany)


4.15-4.30 PM

Re-innervated human skin explant as a model for in vitro studies on pruritus

Nicolas Lebonvallet (France), Christelle Le Gall-Ianotto, Cecilia Brun, Thierry Oddos, Laurent Misery


4.30-4.45 PM

Pharmacological and histochemical characterization of a mouse model of chronic renal failure-associated pruritus

Tsugunobu Andoh (Japan), Shikai Li, Takahito Maki, Daisuke Uta, Yasushi Kuraishi


4.45-5.00 PM

Depressive behavior manifested in NC/Tnd mice suffering from atopic dermatitis

Kenshiro Matsuda (Japan), Shuichi Yanai, Shogo Endo, Akane Tanaka, Hiroshi Matsuda


5.00-5.20 PM

Methods in itch research (experimental)

Landon K Oetjen (USA)


5:30-6:30 PM

General Assembly Meeting

6:30-7:00 PM

IFSI Board Meeting

Tuesday, October 17, 2017

8:30-9:00 AM

Morning session

Hot off the bench: Latest news by young investigators

Chairs: Toshi Ebata (Japan); Andreas Kremer (Germany)

8:30-8:40 AM

Reversing nocebo effects on itch by conditioning with verbal suggestion

Danielle Bartels (The Netherlands), Antoinette van Laarhoven, Michiel Stroo, Kim Hijne Leiden University, Kaya Peerdeman, Rogier Donders, Peter van de Kerkhof, Andrea Evers


8:40-8:50 AM

Amelioration of atopic-itch sensation in NC/Tnd mice by beta-pinene, the major component contained in distilled Alpinia intermedia Gagnep extracts

Yosuke Amagai (Japan), Tetsuyoshi Hamasaki, Yoshihiro Nomura, Hiroshi Matsuda, Akane Tanaka


8:50-9:00 AM

Prolonged antipruritic effect of botulinum toxin type A on cowhage-induced itch

Leigh Nattkemper (USA)



Plenary Session

The wide range of clinical presentations of itch

Chairs: Kenji Takamori (Japan); Gil Yosipovitch (USA)

9:05-9:20 AM

An overview of treatment for opioid-induced itch

Kenji Takamori (Japan), Nobuaki Takahashi, Mitsutoshi Tominaga


9:20-9:35 AM

Pruritus in patients with kidney transplants

Thomas Mettang (Germany), Elke Weisshaar, Jörg Kupfer


9:35-9:50 AM

Urticaria and itch

Tabi Leslie (UK)


9:50-10:00 AM

Essential thrombocythemia with aquagenic pruritus: an entity with more agressive clinical and biological profile at the diagnosis and a high morbidity during the follow-up.

Christelle Le Gall-Ianotto (France), Ronan Le Calloch, Aurélie Chauveau, Eric Lippert, Laurent Misery, Jean-Christophe Ianotto


10:00-10:10 AM

Prevalence and clinical characteristics of pruritus in patients with cutaneous lupus erythematosus

Dominik Samotij (Poland), Justyna Szczęch, Emiliano Antiga, François Chasset, Aleksandra Dańczak-Pazdrowska, Adriana Polańska, Fukumi Furukawa, Carolyn Kushner, Hideo Hashizume, Mohammad Rafiqul Mowla, Aminul Islam, Minoru Hasegawa, Laurent Misery, Takaharu Ikeda, Zygmunt Adamski, Jacek C. Szepietowski, Victoria Werth, Adam Reich


10:10-10:20 AM

Clinical characteristics of aquagenic pruritus in polycythemia vera

Edyta Lelonek (Poland), Łukasz Matusiak, Tomasz Wróbel, Jacek Kwiatkowski, Jacek C. Szepietowski


10:20-10:30 AM

Clinical characteristics of pruritus in hidradenitis suppurativa patients.

Lukasz Matusiak (Poland), Justyna Szczęch, Karolina Kaaz, Edyta Lelonek, Jacek C. Szepietowski


11:15-12:45 PM

Concurrent I

Patients’ perspectives and patient reported outcomes

Chairs: Christian Apfelbacher (Germany); Lidia Rudnicka (Poland)

11:15-11:30 AM

Patient-reported outcomes: an introduction

Christian Apfelbacher (Germany), Pauline Nelson


11:30-11:45 AM

High levels of acting with awareness go along with low levels of itch catastrophizing: First results of a cross-sectional study in patients with atopic dermatitis

Christina Schut (Germany), Kerry Montgomery, Kjell Lüßmann, Andrew Thompson, Uwe Gieler, Christoph Zick, Jörg Kupfer


11:45 AM-12:00 PM

Do placebo effects work when subjects know that they receive a placebo? Effects of open-label verbal suggestions on itch

Stefanie Meeuwis (The Netherlands), Henriët van Middendorp, Judy Veldhuijzen, Antoinette van Laarhoven, Jan De Houwer, Andrea Evers


12:00-12:15 PM

A qualitative study to understand patients’ perception of the severity of chronic pruritus and its impact on health-related quality of life

Jennifer Theunis, Clementine Nordon, Ylana Chalem, Massimiliano Orri, Jesus Cuervo, Gilles Berdeaux, Marie Auges, Valerie Mengeaud, Laurent Misery (France)


12:15-12:30 PM

The burden of chronic itch-a questionnaire based evaluation of clinical characteristics, associated morbidity and treatment outcomes in a cohort of patients with chronic pruritus.

Ian McDonald (Ireland), Imre Szabó Lőrinc, Attila Szöllősi, Martin Steinhoff


12:30-12:45 PM

European EADV network on assessment of severity and burden of Pruritus (PruNet): validation of instruments for itch intensity itch-impaired quality of life in pruritic dermatoses in Europe

Claudia Zeidler (Germany), Philipp Bruland, Claudia Riepe, Inaki Soto, Sabine Steinke, Michael Storck, Martin Dugas, Sonja Ständer


11:15-12:45 PM

Concurrent II

Itch and pain

Chairs: Uli Zeilhofer (Switzerland); Frank Brennan (Australia)

11:15-11:35 AM

Spinal GABA-A receptor subtypes controlling itch

William T. Ralvenius, Elena Neumann, Mario A. Acuña, Martina Pagani, Dietmar Benke, Hendrik Wildner, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer (Switzerland)


11:35-11:55 AM

Opposing effects of cervical spinal cold block on spinal itch and pain transmission

Earl Carstens (USA), Iodi Carstens, T. Akiyama, A. Davoodi, M. Nagamine


11:55 AM-12:15 PM

Responses single thalamic units to pruriceptive and nociceptive stimuli in the rat.

Glenn Giesler (USA), Brett Lipshetz, Hai Truong, Sergey Khasabov, Donald Simone


12:15-12:30 PM

Acupuncture for pain management in evidence-based medicine

Taqee Ansari Mohammed (India)


12:30 AM-12:45 PM

Itch and pain influence on quality of life and sleep disturbances of hidradenitis suppurativa patients

Karolina Kaaz (Poland), Łukasz Matusiak, Jacek C. Szepetowski


12:45 PM-

2:00 PM

Lunch and poster viewing II

Chairs: Elke Weisshaar (Germany), Gil Yosipovitch (USA)

2:00-3:30 PM

Concurrent I

Prurigo and other pruritic skin diseases

Chairs: Jeffrey Bernhard (USA); Joanna Wallengren (Sweden)

2:00-2:15 PM

Prurigo and other pruritic skin diseases.

Joanna Wallengren (Sweden)


2:15-2:30 PM

Psoriatic itch 2017

Jacek C. Szepietowski (Poland)


2:30-2:45 PM

Novel definition, classification and terminology of chronic prurigo

Manuel Pedro Pereira (Germany), Sabine Steinke, Sonja Ständer


2:45-3:00 PM

Aprepitant, a NK1-antagonist, administered for 16 weeks reduced itch and supported resolution of skin lesions in a patient with chronic prurigo

Franz J. Legat (Austria), Alexandra Gruber-Wackernagel, Angelika Hofer, Klara Waltner, Peter Wolf


3:00-3:15 PM

Peripheral effects of targeting the neurokinin 1 receptor in chronic prurigo

Konstantin Agelopoulos (Germany), Falk Rülander, Julia Dangelmaier, Tobias Lotts, Karin Loser, Sonja Ständer


3:15-3:30 PM

Neurophysiological studies on chronic prurigo

Manuel Pedro Pereira (Germany), Konstantin Agelopoulos, Esther Pogatzki-Zahn, Sonja Ständer


2:00-3:30 PM

Concurrent II

New receptors, channels and pathways for itch

Chairs: Ethan Lerner (USA); Yang-Gang Sun (China)

2:00-2:15 PM

Neural recruitment and Mrgpr activity are required for the development of a mouse model of atopic dermatitis

Ethan Lerner (USA), Tuanlian Luo, Ehsan Azimi, Vemuri Reddy, Sarina Elmariah


2:15-2:30 PM

A central feedback neural circuit gates itch-scratching cycle

Yan Gang Sun (China)


2:30-2:45 PM

TRPV1 regulates PAR-2-evoked intracellular Ca2+ release and inflammatory mediators production in differentiated keratinocytes

Olivier Gouin, Killian L’herondelle, Raphaele Le Garrec, Paul Buscaglia, Olivier Mignen, Christelle Le Gall-Ianotto, Virginie Buhé, Luc Lefeuvre, Laurent Misery, Nicolas Lebonvallet (France)


2:45-3:00 PM

Spinal release of gastrin releasing peptide (GRP) is required for suprathreshold synaptic activation of GRP receptor (GRPR)-positive neurons

Martina Pagani (Switzerland)


3:00-3:15 PM

Effects of burn size on post-burn itch and epidermal nerve innervation in mice

Kent Sakai (USA), Kristen Sanders, Gil Yosipovitch, Tasuku Akiyama


3:15-3:30 PM

Possible role of satellite glial cell derived lipocalin-2 in the pathogenesis of atopic dermatitis

Nobuaki Takahashi (Japan), Mitsutoshi Tominaga, Ryohei Kosaka, Hironori Matsuda, Yasushi Suga, Kenji Takamori


4:00-5:15 PM

Concurrent I

Epidemiology of itch and quality of life

Chairs: Suphey Chen (USA); Andrey Lvov (Russia)

4:00-4:15 PM

Epidemiological study on the prevalence of itch in Japanese dementia patients

Toshiya Ebata (Japan), Lefkos Middleton, Ryoko Fukuda, Yoshimasa Takase, Nao Taniguchi, Kimitoshi Takemura, Didier LeClercq, Joelle Vaglio, Michel Poncet, Akihiko Ikoma


4:15-4:30 PM

Pitfalls in pediatric self-reported pruritus severity and quality of life impact

Shelby Smith, Grace Lee, Sandy François, Alix Pijeaux, Kuang-Ho Chen, James Roberts, Suephy Chen (USA)


4:30-4:45 PM

Quality of life in patients with chronic pruritus: from the conceptual model to items generation

Jennifer Theunis, Clementine Nordon, Ylana Chalem, Massimiliano Orri, Jesus Cuervo, Gilles Berdeaux, Marie Auges, Valerie Mengeaud, Laurent Misery (France)


4:45-5:00 PM

Chronic itch (CI) in hemodialysis patients: A follow-up study of GEHIS (German Epidemiological Hemodialysis-Itch Study) on incidence and mortality of patients with CI

Katarzyna Grochulska (Germany), Robert Ofenloch, Thomas Mettang, Elke Weisshaar


5:00-5:15 PM

Prevalence, characteristics and burden of pruritus in chronic dermatoses

Tomasz Hawro (Germany), Katarzyna Przybylowicz, André Ellrich, Max Spindler, Karsten Weller, Sabine Altrichter, Ulrich Reidel, Marcus Maurer, Martin Metz


4:00-5:15 PM

Concurrent II

New imaging techniques and other aspects of itch

Chairs: Clemens Forster (Germany); Ichiro Katayama (Japan)

4:00-4:15 PM

New methods in brain imaging techniques

Clemens Forster (Germany)


4:15-4:30 PM

Three dimensional analysis of cutaneous nervous system in pruritic atopic dermatitis and psoriasis skin

Hong Liang Tey (Singapore)


4:30-4:45 PM

Functional connectivity reveals altered activation of brain areas in chronic cholestatic pruritus

Andreas Kremer (Germany), Theresa Buchwald, Marcel Vetter, Arnd Dörfler, Clemens Forster


4:45-4:55 PM

Itch Tracker: An application software turning wearable smart devices into a tool to measure nocturnal scratching

Akihiko Ikoma (Japan), Kimitoshi Takemura, Didier LeClercq, Toshiya Ebata


4:55-5:05 PM

Changes in tactile sensitivity after viewing itch-related images

Michellie Young (UK), Melanie Burke, Donna Lloyd


5:05-5:15 PM

Keratinocyte derived cortisol regulates itch evoked- allergic cutaneous inflammation

Ichiro Katayama (Japan), Akira Matsumoto, Saori Ochi, Mika Terao, Hiroyuki Murota


5:20-6:30 PM

Plenary Session

Future perspectives

Chairs: Earl Carstens (USA); Elke Weisshaar (Germany)

5:20-5:40 PM

Future perspectives in treatment of itch

Sonja Ständer (Germany)


5:40-6:00 PM

Future perspectives in basic research of itch: Mrgpr receptors and the biology of itch

Xingzhong Dong (USA)


6:00-6:30 PM


6:00-6:15 PM

Handwerker Prize, poster prizes

6:15-6:30 PM

Closing remarks

Jacek C. Szepietowski (Poland), Earl Carstens (USA)