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Original report

Increased interstitial concentrations of pyruvate and lactate in the trapezius muscle of patients with fibromyalgia – a microdialysis study

doi: 10.2340/16501977-0581

Open access


OBJECTIVE: The aim of this study was to compare the interstitial concentrations of pyruvate, lactate and glutamate in the trapezius muscle between patients with fibromyalgia syndrome and healthy controls.
DESIGN: Comparative cross-sectional study.
SUBJECTS: Patients with fibromyalgia (n = 19) and healthy controls (n = 19); all women.
METHODS: Subjects answered a questionnaire about different aspects of pain. Pressure pain thresholds over the trapezius and tibialis anterior muscles were determined. The inter­stitial concentrations of pyruvate, lactate and glutamate were determined in the resting trapezius muscle by the microdialysis technique, with samples collected every hour for 5 consecutive hours. Pain intensity was also rated.
RESULTS: Significantly higher interstitial concentrations of pyruvate and lactate were found in patients with fibromyalgia­ syndrome. The multivariate regression analyses of group membership and pressure pain thresholds of the trapezius confirmed the importance of pyruvate and lactate.
CONCLUSION: Different mechanisms that may increase pyruvate and lactate in patients with fibromyalgia syndrome are discussed. Improved understanding of peripheral muscle alterations in patients with fibromyalgia syndrome could lead to mechanism-based rehabilitation.


Björn Gerdle, Kristina Söderberg, Laia Salvador Puigvert, Lars Rosendal, Britt Larsson


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Volume 42, Issue 7

DOI: 10.2340/16501977-0581

Pages: 679-687

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