Content - Volume 98, Issue 4

This study demonstrates increased splenic inflammation in patients with psoriasis compared with age-matched control subjects. Given the well-established role of the spleen in systemic inflammatory diseases, this provides evidence of systemic inflammation in psoriasis beyond that reported by biomarker studies. Additionally, a significant association between splenic inflammation and aortic wall inflammation was found in psoriasis patients. Taken together, this study provides evidence supporting a spleen-atherosclerotic inflammatory axis in psoriasis.

• This study underscores the efficacy of the strategy combining targeted Next-generation Sequencing with immunofluorescence mapping (IFM) in resolving unusual epidermolysis bullosa phenotypes. It also suggests that, in spite of technological advances careful clinical evaluation and deep phenotyping remain crucial factors for successfully establishing epidermolysis bullosa diagnosis. IFM, an almost 40 year-old method delivers the correct classification of epidermolysis bullosa in more than 70% of the cases.

The spleen is thought to play a role in atherosclerosis-associated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography-computed tomograph ...

This study investigated the prevalence of psoriasis and trends in prescription of medications for patients with psoriasis using the Korean National Health Insurance Claims Database from 2006 to 2015. The prevalence of psoriasis and psoriatic arthritis per 10,000 people increased from 47.4 to 61.5 and from 0.04 to 0.23 respectively. The prescription of topical agents was a mean of 73.3%. For system ...

DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. All the patients had skin eruption, 83% had l ...

Nivolumab response rate is 40% in metastatic melanoma. Few studies have evaluated pre-treatment biomarkers predictive of response. The aim of this study was to identify potential peripheral blood biomarkers associated with survival in patients with advanced melanoma treated with nivolumab. All advanced melanoma cases treated with anti-programmed cell death protein 1 (anti-PD1) over a 3-year period ...

Circulating anti-type VII collagen autoantibodies are frequently detected in patients with recessive dystrophic epidermolysis bullosa (RDEB). However, evidence supporting their pathogenic role in inducing epidermolysis bullosa acquisita (EBA) has been provided for only one individual with dominant dystrophic epidermolysis bullosa (DDEB). We describe here a patient who presented with dystrophic toe ...

Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders were given the opportunity to continu ...

Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense lateral lipid organization. In addition, parakeratosis was occasionally observed. The present study investigated whether the extent of initial bar ...

Changes in the skin microbiome have been shown to promote cutaneous inflammation. The skin microbiome of patients with chronic plaque type psoriasis was analysed before and after treatment with narrowband ultraviolet B (UVB). Swab samples of the microbiome were taken from lesional and non-lesional skin of 26 patients. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the Ill ...

The precise classification of epidermolysis bullosa (EB) into 4 main types and more than 30 subtypes is based on the level of skin cleavage, as well as clinical and molecular features, and is crucial for early prognostication, case management, genetic counselling and prenatal or pre-implantation diagnosis. We report here the molecular pathology of 40 consecutive cases of suspected EB, which were i ...

Perceptions of the clinical management of delusional infestation (DI) were compared with clinical outcomes in this 10-year case series from a single centre in Dundee, UK. An online questionnaire (survey-monkey, a TM brand of online survey available for free for basic use) was sent to Scottish Dermatologists to gauge their opinions and confidence in the management of DI. Also, a retrospective revie ...

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract s missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Short communication)

Abstract is missing (Quiz)

Abstract is missing (Quiz)

Abstract is missing (Quiz)

Abstract is missing (Quiz)

Abstract is missing (Quiz)