Content - Volume 84, Issue

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A mathematical model is described that predicts the response of psoriasis to a treatment course of UVB irradiation. The basis of the model is that UVB acts by a direct effect on keratinocytes and that cell cycle arrest is the major mode of action in the phototherapeutic response in psoriasis. Although it is unlikely that UVB causes resolution of psoriatic plaques through a single mechanism, the cu ...

Epidermal keratinocytes are heterogeneous and can be divided into stem cells (strong β1-integrin expression) with unlimited clonogenic potential, transient amplifying cells (weaker β1-integrin expression) with restricted proliferative capacity and terminally differentiated cells (no β1-integrin expression) that have lost the capacity to divide. We tested the hypothesis that cell kinetic charact ...

Thenaevus profile was examined in a Swedish cohort of 8-9-year-oldchildren; 524/545 individuals (96%) were examined (279 boys and 245girls). There was a wide variation in the total number of naevi (0-79)and boys had more naevi than girls (median 9 and 7, respectively, p<0.01).No dysplastic naevi were found. Overall, 15/524 (3%) had at least onelesion clinically diagnosed as a congenital melanocyt ...

The aim of this study was to confirm findings that vapour-impermeable panty liners might impair skin climate, and to assess their impact on the skin microflora. Temperature, surface pH and aerobic microflora were measured on vulvar skin of 102 women. The mean skin temperature was 1.1 degrees C higher when using a vapour-impermeable panty liner compared with not using one. Use of panty liners with ...

Theconstant increase of life expectancy in countries with high standardsof living raises growing concern about many aspects of skin morbidityin the elderly. As regards seborrhoeic dermatitis, literature yieldsprevalence estimates for elderly people that are consistently higherthan those reported from the general population. This promptsspeculations on whether factors inherently involved in senesce ...

Skintests with autologous serum elicit an immediate wheal-and-flareresponse in about 30-50% of chronic idiopathic urticaria subjects,suggesting that an autoimmune mechanism might be involved in thepathogenesis of this disease. The aim of the present work, involving 68subjects with chronic idiopathic urticaria, was to distinguish betweenthe serum-positive and serum-negative cases and highlight the ...

Itis known that cosmetics and skin care products can cause adverse skinreactions. However, the frequency of adverse reactions reported to theMedical Product Agency (MPA) in Sweden is low. The purpose of thepresent study was to evaluate the occurrence of adverse skin reactionsto cosmetics among patients referred for standard patch testing owingto suspected contact dermatitis in general, most freque ...

The aim of this study was to evaluate the clinical manifestations of cutaneous graft-versus-host disease (GVHD) developed after allogeneic haematopoietic cell transplantation. In all, 67 patients were evaluated: 49 patients developed acute GVHD, 17 patients developed de novo chronic GVHD and 29 developed secondary chronic (15 limited, 14progressive) GVHD following acute cutaneous GVHD. Of the 46 ...

UVB-TL01 is proven to be efficient in whole body treatment for several chronic inflammatory dermatoses. Chronic hand dermatoses of different and oftenmixed genesis represent a great problem in clinical practice. We have performed a prospective, open study with patients suffering frompsoriasis, eczema or pustulosis of the hands treated with hand UVB-TL01. Thirty patients (23 women and 7 men) were i ...

Eosinophilicpustular folliculitis is characterized by an eosinophil-richinflammatory follicular and perifollicular infiltrate primarily centredat the level of the follicular isthmus and sebaceous duct. Follicularmucinosis has been observed in lesions of eosinophilic pustularfolliculitis. Clinical and histological features of eosinophilicpustular folliculitis with follicular mucinosis and alopecia ...

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