Content - Volume 81, Issue

The concept of antisense technology is elegant but misleadingly simple. Short oligodeoxynucleotides (ODNs) complementary to a target messenger RNA form DNA-RNA hybrids by WatsonCrick base pairing rules, and interfere with expression of the encoded protein. The potential sequence specificity of antisense ODNs makes them attractive as molecular drugs in the treatment of human diseases. The skin is r ...

Perfluoropolyethers (Fomblin® HC products) are chemical nonreactive polymers with special physico-chemical properties that recently showed promise as protective preparations in the prevention of irritant contact dermatitis. We evaluated the efficacy of a new class ofperfluoropolyethers (perfluoropolyether phosphate , Fomblin® HC/P2) in the prevention of experimentally induced cumulative irritan ...

Skin irritation is mostly a multifactorial process. Competitive effects of different chemical irritants are well known. This study investigates the influence of a thermal stimulus on skin pre-irritated with sodium lauryl sulfate (SLS). Seventy-seven volunteers were patch-tested with SLS 0.25% and 0.5% for 48h. Water served as control. Skin reaction was evaluated by measurement of transepidermal wa ...

The aim of the study was to investigate the effect of non-allergenic structural analogues on the sensitizing potential of carvone, a fragrance allergen. The possibility that one molecule might inhibit the allergenic activity of another molecule has been debated for 25 years. The Research Institute for Fragrance Materials states that the sensitizing activity from certain fragrance aldehydes is "que ...

Irritant contact dermatitis has a broad spectrum of clinical features and is a leading cause of occupational disease worldwide. It has been shown previously that a combination of chemically different irritants may cause an additive effect compared to single application of these substances. In this study, tandem application of sodium lauryl sulfate and n-propanol was investigated in 20 human volunt ...

Pseudomonas aeruginosa colonizes 20-30 % of all venous leg ulcers. Hypothetically, P. aeruginosa could release proteases and cytotoxic substances in the environment of chronic ulcers, thus negatively affecting the wound-healing activity in this patient group. Here we show that P. aeruginosa isolates from leg ulcers exhibit a highly variable expression of the proteinases elastase and alkaline pr ...

Psychiatric disorders are frequent among patients with skin diseases. We aimed at identifying factors associated with psychiatric morbidity in dermatological outpatients. All adults attending the outpatient clinics of a dermatological hospital on predetermined days were given the 12-item General Health Questionnaire. The dermatologists indicated the diagnosis and location of skin lesions and rated ...

Non-melanoma skin cancer is historically known to be associated with certain professions. Reporting is mandatory in Denmark when occupational exposure is suspected. In a retrospective register-based study of all cases of suspected occupational non-melanoma skin cancer reported to the Directorate of National Labour Inspection and the National Board of Industrial Injuries in Denmark in the period Ja ...

IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1, rMal f 5-9) from M. furfur . In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur -associated AD compared with the M. furfur extra ...

The aim of the present prospective study was to substantiate possible side effects of short-term oral acitretin therapy (1mg/ kg/day) on peripheral nerve function of 13 patients with severe keratinization disorders. Clinical neurological examination before and 1 and 3 months after onset of treatment was unremarkable in all patients; however, a significant alteration of one or more neurophysiologic ...

Gemcitabine is considered to be a well-tolerated and safe cytostatic drug because of the relative lack of side effects. Cutaneous reactions due to gemcitabine treatment, including alopecia and maculopapular eruption, are well known. We report one patient with squamous cell carcinoma of the lung who developed a gemcitabine-induced cutaneous reaction mimicking acute lipodermatosclerosis. This case ...

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