Content - Volume 78, Issue

Atopic dermatitis has many similarities with allergic contact dermatitis. Previous studies have revealed delayed-type allergic reactions indicating specific cell-mediated immune reactions in subgroups of patients. It has recently been recognized that purified house dust mite major allergens, Der p1 and Der p2 from Dermatophagoides pteronyssinus , exhibit a proteolytic enzyme activity similar to ...

Twenty-four-hour occlusive exposures of 1% aqueous sodium lauryl sulfate (SLS) produced unique functional and histological responses in patients with atopic dermatitis. Disruption of the stratum corneum barrier, measured by transepidermal water loss, was much greater and longer lasting than in normal controls. In contrast to controls the histologic pattern induced reproduced the typical features ...

Apoptosis is a form of cellular suicide and is activated in various cells, including keratinocytes, in response to physiological and pathological stimuli. A current hypothesis holds that apoptotic cells in a concerted manner express characteristic phenotypic features comprising cytoplasmic budding, pyknosis, chromatin condensation, karyorhexis and internucleosomal DNA fragmentation. In this study ...

Posture-induced microcirculatory changes in the lower leg were studied in venous leg ulcer patients and in control subjects by means of laser Doppler imaging (LDI), a technique which allows almost real-time mapping of the perfusion from a distance, each perfusion value constituting the mean of a number of measurements at separate sites. LDI values for intact skin with the subject supine were 0.39 ...

In connection with a national cost-effective evaluation study of short contact dithranol therapy for psoriasis, the question arose whether dithranol cream irritation is influenced by constituents of the vehicle. To establish the role of the different components of the vehicle in the mechanism of dithranol irritation, the dithranol 3% cream used in the evaluation study and its vehicle with nine di ...

Although dietary vitaminA is required for normal growth and development, long-term or high-dose administration of vitaminA derivatives (retinoids) may produce a variety of skeletal side-effects in man. In this study we investigated the early effects of oral isotretinoin therapy on bone turnover and calcium homeostasis in eleven consecutive patients with nodulocystic acne. The effects on bone meta ...

The effect of 3 protective creams and petrolatum was tested in a repetitive irritation test. On 15 healthy volunteers, the irritants (sodium lauryl sulfate 10%, sodium hydroxide 0.5%, lactic acid 15%, and toluene undiluted) were applied on the paravertebral skin of the mid-back after 30 min pretreatment with the products tested. The volunteers were treated for 9 days. The irritant cutaneous react ...

Our aim was to assess the microdialysis technique for determining in vivo drug levels of a lipophilic and a protein-bound model drug in the dermis. Forearm skin of healthy volunteers received topical 2% fusidic acid or 0.1% betamethasone-17-valerate formulations twice daily as occluded treatment on irritative dermatitis. Microdialysis sampling in the dermis after 48 h was without measurable drug ...

Changes in stratum corneum properties due to sodium lauryl sulfate cumulative irritation were determined as a function of age. We irritated the backs of 7 younger (27.7±4.6 years, mean±standard deviation) and 10 older (69.8±5.5 years) volunteers on 5 consecutive days with open application of a 7.5% aqueous sodium lauryl sulfate solution. Water- and untreated skin served as controls. Transepide ...

While the early detection of malignant melanoma is important and has been emphasized widely in the past few years, it is difficult to accomplish. The purpose of this study is to assess how well dermatologists recognize malignant melanomas in patients with naevi. Information from 9,121 patients visiting two dermatological clinics in Stockholm and diagnosed melanocytic naevi was linked with the Swe ...

One-hundred-and-seventy-seven cases of cutaneous malignant melanoma were reported to the Swedish National Cancer Registry in subjects below the age of 20 during the period 1973-92. One-hundred-and-fifty-four (87%) were re-examined histologically, and the original diagnosis of primary cutaneous malignant melanoma was verified in 88%. The age-specific mean annual incidence rate increased to 0.5/100 ...

To ascertain the prevalence of childhood and adolescent atopic dermatitis in a Japanese population, we clinically observed the total body of 5 to 6-year-old children (994 cases), 7 to 9-year-old children (1,240 cases), 10 to 12-year-old children (1,152 cases), 13 to 15-year-old children (1,670 cases), and 16 to 18-year-old adolescents (2,159 cases). The examination was performed in the spring of ...

A case of pemphigus foliaceous is presented, where the disease has been successfully controlled with plasma exchange therapy alone for 10 years.

A randomized, double-blind, placebo-controlled study was conducted to compare the efficacy of ammonium solution with placebo in relieving type I symptoms caused by Aedes aegypti mosquitoes on 25 healthy subjects. Each subject was bitten once under laboratory conditions by Aedes aegypti mosquitoes on the volar aspect of each forearm, and then received the treatment with ammonium solution and pla ...

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