Content - Volume 77, Issue 5
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All articles
INVESTIGATIVE REPORT
Ramsing DW, Agner T.
The effect of a moisturizer was tested on experimentally irritated human skin in two studies. In a prevention study, 12 volunteers had both hands immersed into a 0.375% sodium lauryl sulphate solution, 10 min twice daily for 2 days. Before each immersion one hand was treated with the moisturizer; the other hand served as control. In a therapeutic study, 12 volunteers had both hands immersed in the ...
Pages: 335-337
INVESTIGATIVE REPORT
Talme T, Schultzberg M, Sundqvist KG, Marcusson JA.
This study presents an immunohistochemical characterization of somatostatin-positive dendritic cells in psoriatic lesions. Somatostatin is a neuropeptide with inhibitory action on several neuropeptides and hormones, but also with immunomodulating properties, and has been used in several studies as treatment for psoriasis. The number of somatostatin-positive dendritic cells was found to be larger i ...
Pages: 338-342
INVESTIGATIVE REPORT
Michaëlsson G, Kraaz W, Hagforsen E, Pihl-Lundin I, Lööf L, Scheynius A
The aim of this work was to study tryptase+ mast cells and CD3+ T lymphocytes in non-involved skin in psoriasis and their possible relation to mast cells and lymphocytes in the duodenal mucosa. Skin biopsy specimens were obtained from 43 patients with psoriasis of variable severity and from 10 healthy subjects. Compared with the reference subjects, the number of mast cells in non-involved skin was ...
Pages: 343-346
INVESTIGATIVE REPORT
The case of unusual desmoplastic variant of trichilemmoma arising in the neck of a 56-year-old man is reported. The tumour was characterized by the presence of a densely sclerotic stroma, surrounded by lobules of epithelial cells with features of outer root sheath differentiation, including glycogen-rich, clear cytoplasm and peripheral palisading. In the central part of the tumour, irregular cords ...
Pages: 347-349
INVESTIGATIVE REPORT
Billoni N, Gautier B, Mahé YF, Bernard BA
Since clinical evidence of hair loss and hair depigmentation following etretinate therapy has been reported, we decided to study the expression levels of several members of the retinoid nuclear receptor superfamily in dermal and epithelial compartments of the human hair follicle. Additionally, we evaluated the effects of several ligands for these receptors on human hair growth in culture in vitro. ...
Pages: 350-355
INVESTIGATIVE REPORT
de Jong EM, van der Vleuten CJ, van Vlijmen-Willems IM
Lichen planus (LP) and discoid lupus erythematosus (DLE) are separate disease entities. Nevertheless, patients with a so-called "overlap syndrome" have been described occasionally. The aim of the present study was to establish whether the LE/LP overlap syndrome, based on clinical and routine histological features, could be delineated from DLE or LP using immunohistochemical techniques. Formalin-fi ...
Pages: 356-360
INVESTIGATIVE REPORT
Eicheler W, Huth A, Happle R, Hoffmann R
The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I. Although this process is only incompletely understood, the dermal papilla as a pivotal part of the hair follicle is almost certainly involved. Since protein kinase C (PKC) isoenzymes are activated by pho ...
Pages: 361-364
INVESTIGATIVE REPORT
Katoh N, Hirano S, Kishimoto S, Yasuno H.
Perturbation of the cutaneous water permeability barrier has been shown to result in many physiological events in keratinocytes, including upregulation of proinflammatory cytokine production. However, little is known about the effect of barrier disruption on Langerhans' cells (LC). In the present study, we examined whether acute barrier perturbation by acetone treatment or tape stripping affects t ...
Pages: 365-369
CLINICAL REPORT
Möller H, Svensson A, Björkner B, Bruze M, Lindroth Y, Manthorpe R, Theander J
Patients with rheumatoid arthritis were investigated for contact allergy to gold in connection with treatment with gold preparations. There were 57 patients with rheumatoid arthritis previously treated with gold, with or without cutaneous side-effects, as well as 20 patients intended for such treatment; all were exposed to patch and intradermal tests with gold sodium thiosulfate, gold sodium thiom ...
Pages: 370-373
CLINICAL REPORT
Breitbart M, Garbe C, Büttner P, Weiss J, Soyer HP, Stocker U, Krüger S, Breitbart EW, Weckbecker J, Panizzon R, Bahmer F, Tilgen W, Guggenmoos-Holzmann I, Orfanos CE
The present study firstly aimed at understanding the relationship between sun exposure, pigmentary traits and the history of sunburns. Secondly, the significance of UV-exposure for cutaneous melanoma and for melanocytic naevi was investigated. The case-controlled study comprised 513 patients with primary cutaneous melanoma and 498 controls matched by age and gender. Multivariate logistic regressio ...
Pages: 374-378
CLINICAL REPORT
The urinary excretion of 5-S-cysteinyldopa (5-S-CD) is known to be increased in certain patients with melanoma. To evaluate its diagnostic and prognostic utility, we measured the urinary excretion of 5-S-CD on at least three different occasions in 50 patients with melanoma. No significant increase was found in 26 patients without metastases, in 10 patients with regional lymph node metastasis and 2 ...
Pages: 379-381
CLINICAL REPORT
Ichikawa MM, Ishida-Yamamoto A, Hashimoto Y, Matsuo S, Iizuka H
We present a case of (arterio) venous hemangioma of 15 years' duration, which arose in a 43-year-old Japanese man on his right infraorbital area. Elastic stain and electron microscopy did not show any evidence for arterial components. Some thick-walled vessels showed mucin deposition and wide intercellular spaces between smooth muscle cells. Several glomoid cells were encountered among these cells ...
Pages: 382-384
CLINICAL REPORT
Neumann NJ, Kerscher M, Ruzicka T, Lehmann P
Administration of 8-methoxypsoralen in a dilute bath water solution is an effective therapeutic alternative to its systemic application, avoiding systemic side effects. Although PUVA bath photochemotherapy is now widely used, standardized guidelines are not yet available. Therefore, the aim of our study was to determine the optimal time interval between 8-methoxypsoralen bath and UVA irradiation a ...
Pages: 385-387
CLINICAL REPORT
Matsumura N, Aiba S, Tanaka M, Aoyama H, Tabata N, Tamura G, Tagami H
To clarify the pathomechanisms underlying the involvement of different organs by atopic dermatitis (AD) and allergic respiratory disease (ARD), we compared the immune reactivities to various environmental allergens between 46 adult patients who suffered only from AD but were without any history of ARD and 41 patients who had only ARD, using a RAST FEIA (radioallergosorbent test/fluoroenzyme immuno ...
Pages: 388-391
CLINICAL REPORT
Jemec GB, Wulf HC
The lack of standard systems for assessment of disease severity poses a problem for the introduction of rational quality control in dermatology. The scoring systems often involve assessment of the same aspects of disease, and it may therefore be conceivable that one system could potentially be applied to routine clinical work and form the basis of disease quantification in dermatology. This study ...
Pages: 392-393
CLINICAL REPORT
Palatsi R, Ruokonen A, Oikarinen A
Isotretinoin, used to treat severe acne, has been shown to induce hormonal changes, especially to reduce 5 alpha-reductase in the production of the tissue-derived dihydrotestosterone (DHT) metabolite 3 alpha-Adiol G. However, the effects of isotretinoin on other pituitary, adrenal or gonadal hormones have not been thoroughly elucidated. In the present study, isotretinoin administered at a dose of ...
Pages: 394-396
LETTER TO THE EDITOR
Siragusa M, Batolo D, Schepis C
No Abstract available
Pages: 397-397
LETTER TO THE EDITOR
Petersen AA, Bech-Thomsen N, Mainolfi EA, Wulf HC, Vejlsgaard GL
No Abstract available
Pages: 398-399
LETTER TO THE EDITOR
Rozell B, Grevér AC, Marcusson JA
No Abstract available
Pages: 399-400
LETTER TO THE EDITOR
Molin L
No Abstract available
Pages: 401-402
LETTER TO THE EDITOR
Molin L, Larkö O
No Abstract available
Pages: 402-402
LETTER TO THE EDITOR
Rongioletti F, Basso GI, Sementa A, Gambini C, Rebora A
No Abstract available
Pages: 403-403
LETTER TO THE EDITOR
Yalçin B, Sahin S, Ciliv G
No Abstract available
Pages: 403-404
LETTER TO THE EDITOR
Kawaguchi H, Kawaguchi T, Ishii N, Nakajima H, Ichiyama S
No Abstract available
Pages: 405-406
LETTER TO THE EDITOR
De Simoni I, Iacovelli P, Lunghi F, Peris K, Chimenti S
No Abstract available
Pages: 406-407
LETTER TO THE EDITOR
Verma KK, Pasricha JS
No Abstract available
Pages: 407-408
LETTER TO THE EDITOR
Weisshaar E, Sabel R, Gollnick H
No Abstract available
Pages: 408-409
LETTER TO THE EDITOR
Barbareschi M, Sibillo E, Greppi F, Bruscagin C, Crosti C
No Abstract available
Pages: 409-410
LETTER TO THE EDITOR
Dewerdt S, Machet L, Jan-Lamy V, Lorette G, Therizol-Ferly M, Vaillant L
No Abstract available
Pages: 411-411
LETTER TO THE EDITOR
Ramam M, Dogra D
No Abstract available
Pages: 411-412
LETTER TO THE EDITOR
Cohen PR, Kurzrock R
No Abstract available
Pages: 412-413
LETTER TO THE EDITOR
Becker LR, Lutz C, Erbard H, Bröcker EB, Hamm H
No Abstract available
Pages: 413-413