Content - Volume 68, Issue 5

Recent studies suggest that the immune system is involved in the pathogenesis of psoriasis. We studied the expression and distribution of immunocompetent cells and of some chosen differentiation antigens of keratinocytes at various stages of lesion development, using indirect and amplified immunofluorescence, and avidin-biotin-peroxidase method. Serial cryostat sections were collected so as to all ...

The scleroderma-inducing N-sulfated glycosaminoglycan previously isolated by us from the urine of patients with systemic scleroderma was further purified: it was biochemically characterized by low O-sulfation and relative high N-sulfation. Consistent with this finding, desulfated and N-resulfated heparin, which had a similar composition to the urine-derived scleroderma-inducing glycosaminoglycan, ...

5-S-Cysteinyldopa (5-S-CD), a pheomelanin precursor, has been used as a biochemical marker of melanoma metastasis. Recently, 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C), a eumelanin-related metabolite, was shown to reflect well the degree of skin pigmentation. We measured the urinary excretion of 5H6MI2C and 5-S-CD in mice bearing B16 melanoma to determine which of the two markers better ...

Histological diagnosis of superficial spreading melanoma (SSM) of invasive type was found to vary significantly with season, such cases being most numerous in April-September. Cases of in situ type were evenly distributed throughout the year. This distinction has not been made previously. It suggests that different mechanisms may be involved in the development of these two lesions. The results as ...

Nickel-specific T cells were primed in vitro and restimulated with nickel in combination with autologous or allogeneic antigen-presenting cells. We have previously shown that not only DR, but also DQ molecules may take part in this process. To investigate this phenomenon further we applied recently available knowledge based on studies using specific cDNA probes and Restriction Fragment Length Poly ...

A statistical study of the relationship between vesicular palmar eczema and various clinical variables was carried out. Vesicular palmar eczema was found in 153 cases (38%), thereof 113 females (76%). Ninety-two percent of all found cases could be regarded as pompholyx. Three new pathogenetic factors were suggested in the vesicular palmar eczema: use of acetylsalicylic acid (Aspirin), contraceptiv ...

A single clinical report describes photoallergic contact dermatitis to bisphenol A, with subsequent persistent light reactivity, in a group of eight outdoor workers. In a mouse model we have induced photoallergic contact dermatitis to bisphenol A; sites of photochallenge reactions flared when later tested with UVA alone. Attempts to induce photoallergy to bisphenol A in guinea pigs failed.

One hundred and eighty-five patients with pemphigus vulgaris were treated and followed up over a period of 25 years, from 1962 to 1987, at the Department of Dermatology of Moscow Medical Stomatological Institute. In all these patients the diagnosis was confirmed clinically, histologically and cytologically, and in 152 patients by means of direct and indirect immunofluorescence. The patients were t ...

Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, a dermatosis occurring with high prevalence in symptomatic HIV-infected individuals. Quantitative cultures for P. ovale were taken in 12 HIV-seropositive patients and in 12 HIV-seronegative controls. Sera were analysed for antibodies to P. ovale. In HIV-seropositive patients, lymphocyte subsets were analysed. The ...

Theoretically percutaneous absorption comprises two components: the transepidermal route and the transappendageal route, so-called ´shunt´ diffusion. The relative importance of ´shunt´ diffusion was investigated with a model of appendage-free skin. After treatment with 60 degrees C water for exactly 1 min, hairless dorsal rat skin regrows as a continuous epidermis. We present preliminary resul ...

T lymphocyte and dendritic cell subpopulations were counted in untraumatized, uninvolved skin of 27 patients with psoriasis. Eight of the patients proved to be Koebner-positive, as determined by tape stripping and punch biopsy, and 19 Koebner-negative. In the epidermis the CD4/CD8 T cell ratio was significantly higher in the Koebner-positive vis-?†-vis Koebner-negative patients (median CD4/CD8 = ...

The pharmacokinetics of [75Se-L]-selenomethionine was studied in 10 patients with psoriasis, 10 with atopic dermatitis and 10 healthy subjects. Values for the gut absorption and the rate of endogenous excretion of [75Se-L]-selenomethionine, the exchangeable total-body selenium and plasma selenium concentration showed no significant differences between either patient group and the controls. The res ...

To elucidate the effect of phototherapy on vitamin D metabolism in psoriatics, the serum concentrations of the major vitamin D metabolites (25-hydroxy-vitamin D (25(OH)D), 1,25-dihydroxy-vitamin D (1,25(OH)2D), and 24,25-dihydroxy-vitamin D (24,25(OH)2D)) were studied in 10 patients with disseminated psoriasis, both before and after phototherapy. Some 3-4 weeks of Goeckerman therapy induced signif ...

During a 6-month-period, 150 patients infected with Human Immunodeficiency Virus (HIV) were repeatedly examined by dermatologists and dentists for lesions of skin and oral mucosa. The most frequently encountered diseases were: oral hairy leukoplakia (21%), dermatophytosis (including tinea unguium/tinea pedis et inguinalis) (20%), seborrheic dermatitis (19%), viral infections (10%), oral candidiasi ...

A 74-year-old female patient with an erythrodermic pityriasis rubra pilaris developed multiple seborrheic keratoses during the early stage of the skin disorder. There was no evidence of an underlying internal malignancy. Initially, the patient was treated with etretinate. The seborrheic keratoses all faded away during the next 3-4 months without any specific treatment. The possible role of retinoi ...

A new method for quantitative culture of Pityrosporum yeasts, the ´tape-method´, is presented. Samples for culture were taken from the skin by stripping with 1 cm2 of tape, whereafter the tapes were placed over a drop of sterile olive oil which was pipetted on a Sabouraud medium. Plates were incubated at 37 degrees C, and after 7 days the numbers of Pityrosporum colonies growing under the tapes ...

The effects of repeated applications of low doses of antigen on subsequent delayed cutaneous hypersensitivity (DCH) responses induced by the same antigen were evaluated. Fourteen healthy individuals were tested with seven different antigens given intracutaneously with the Multitest system device (Institute M?©rieux). The procedure was repeated on four occasions at 2-week intervals. At the first t ...

A 27-year-old nickel-sensitive female who had had continuous spontaneous flare-ups of eczema, including at sites of previous metal contact, experienced a clearing of her eruption after commencing a low-nickel diet. When on the diet, whole-blood and urinary nickel levels fell to half or less of pre-diet values and this coincided with the clinical improvement. Low-nickel diets should be considered f ...

A patient suffering from rheumatoid arthritis and hypertension is described who developed pemphigus foliaceus during simultaneous treatment with d-penicillamine and captopril. Discontinuation of the d-penicillamine afforded some improvement, but skin symptoms still persisted after 3 months. When the captopril was discontinued as well, all lesions healed within 2 weeks. Our findings suggest that bo ...

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