Content - Volume 68, Issue

An explant culture model of epidermal cell growth is outlined. Based on sequential measurements of the radius of the outgrowth around the explant, the paper describes two phases of growth. In the first phase, growth depends on migration of cells out from the explant and on their subsequent proliferation by mitosis. This period occurs during the first week after explantation. At a certain point in ...

Irritant dermatitis after application of experimental irritants was studied by means of contact thermography. Sixteen healthy persons were patch-tested, using the following irritants: Sodium lauryl sulphate, benzalkonium chloride, nonanoic acid, hydrochloric acid, croton oil, sapo kalinus and sodium hydroxide. A main finding was that croton oil after 24 h caused a warm skin lesion, and sodium laur ...

Anti-type I and type III collagen polyclonal antibodies and anti-type III collagen monoclonal antibodies were produced using type I and type III collagen extracted from the human placenta. An indirect immunofluorescence technique using these antibodies showed the same distribution of type III as well as type I collagen in the entire dermis of the normal human skin in nearly identical patterns. Pre ...

Reactivity for Ki-1 antibody was studied in 145 patients with a large variety of cutaneous disorders. The antigen was consistently expressed and by a high proportion of tumour cells in infiltrates in which atypical cells revealed a ´histiocytic´ appearance, i.e. lymphomatoid papulosis (LP), T-immunoblastic lymphoma with the characteristic of true histiocytic lymphoma, Hodgkin´s disease, T-blast ...

T lymphocyte and dendritic cell subpopulations were counted in three biopsies each of endogenous eczema and pityriasis rosea and two of lichen planus and compared with previous findings in psoriatic lesions. In common with psoriasis, proportionately more CD4 T cells than CD8 T cells were DR+ in both epidermis and dermis of all lesions. In addition, total numbers of epidermal dendritic cells were s ...

Epidermal Langerhans´ cells (LC) were studied in patients with pustulosis palmoplantaris (PPP) by utilizing the monoclonal antibodies anti-Leu6 and anti-HLA-DR in combination with an immunoperoxidase technique. In non-pustular areas of the skin lesions in PPP, an increased number of epidermal LC was found compared with control subjects. No change in LC counts was observed following etretinate mon ...

The circadian rhythm of melatonin secretion of the pineal gland can be disturbed in a variety of clinical conditions and diseases including some psychic disorders. To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE. In 6 patients exhibiting low serum levels of melat ...

Cutaneous reactions induced by intradermal histamine injection were studied in uremic patients with and without pruritus who were undergoing maintenance hemodialysis and also in healthy subjects. Flare reactions were significantly smaller in both groups of patients than in controls. However, the itch responses following histamine injection were greater in patients with pruritus than in non-pruriti ...

Between 1943 and 1983 a total of 617 patients were diagnosed to have morbus Bowen (m.B.). Eighty percent of the patients were over 60 years old at the time of diagnosis. Three-fourth had their disease on sun-exposed areas (head, neck and hands). Almost 1/4 had concomitant basal cell epithelioma (c.b.) and 1/10 squamous cell carcinoma (c.s.). Approximately 1/5 had multiple m.B. tumours. Effective t ...

Bacterial cultures derived from 432 chronic leg ulcers were analysed retrospectively to determine which bacteria are most commonly found in these ulcers. The study covered a 2-year period. Two-thirds of the patients were over 70 years of age. Staphylococcus aureus was found in nearly half of the ulcers studied, Pseudomonas sp. in one-third, pyogenic streptococci and enterococci in every fifth and ...

A simple method for regulating the highest comfortable sub-bandage pressure is described. One way of regulating the pressure under the bandage is to vary the stretch of the bandage and the other way is to alter the number of bandage layers. With constant stretch, the pressure is proportional to the number of layers. The method with constant degree of stretch and gradually increasing number of laye ...

1,182 males and 155 females attending an STD clinic from June 1984 to October 1985 were investigated for the presence of antibodies to human immunodeficiency virus (HIV). 348 (29.5%) of the males and 5 (3.2%) of the females were antibody positive (ab+). 237 of the males were initially antibody negative (ab-) and were tested more than once, and during a 16-month period 40 of these seroconverted fro ...

Relatively mild exposure of human epidermis to sodium lauryl sulphate caused a general activation of the Langerhans cell system within 5 hours. An unexpected reactive phenomenon was that this irritant caused some cytomembrane parts to fold upon each other, thereby forming numerous Birbeck granules, several of which had an irregular shape. Spotty cytomembrane damage to the Langerhans cells was also ...

To elucidate the pathomechanisms of irritant pustular dermatitis and to evaluate the role of leukocytes in pustulation induced by croton oil, we compared the skin responses in leukopenic-and decomplemented guinea pigs with those in control saline-injected animals, to 1% croton oil application. Both decomplemented and control animals responded similarly to croton oil, showing erythema and pustulati ...

A case of granulomatous contact dermatitis due to gold earrings for pierced ears was studied ultrastructurally. The patient was a 24-year-old woman, who had reddish brown papules on the earlobes. Patch test using gold sodium thiomalate proved strong positive, with blister formation. Histological observation of the papule showed dense cell infiltration throughout the full thickness of the dermis. U ...

A case of benign cephalic histiocytosis in a 18-month-old male child is reported. Characteristic distribution of the maculo-papular lesions on the cheeks, forehead and earlobes, in addition to light and electron microscopical findings permitted the diagnosis of this rare disorder. Ultrastructurally, worm-like and comma-shaped bodies were seen in the cytoplasm of the histiocytes infiltrating the up ...

The pharmacokinetics of methotrexate was studied in 23 patients with chronic plaque psoriasis. Ten patients received a single oral does and 13 patients a single intramuscular injection of 25 mg methotrexate. Serum methotrexate was measured for 24 hours following administration of the drug using a magnetizable solid-phase radio-immunoassay. The disappearance of methotrexate from the serum fitted a ...

Cutaneous blood flow was measured by Laser Doppler Flowmetry after topical application of minoxidil lotion, in 9 healthy males with androgenetic alopecia, and other volunteers. No reaction in the cutaneous blood flow was seen after application of 2%, 5%, or placebo minoxidil lotion.

No Abstract is available

No Abstract is available