Content - Volume 64, Issue 5

Sera from hexachlorobenzene-induced porphyric rats were examined for evidence of complement activation. The serum irradiated in vitro with 405 nm light resulted in a dose-dependent diminution of the total hemolytic activity of the complement. Further, such irradiated serum showed immunoelectrophoretical C3 conversion and chemotactic activity for rat polymorphonuclear leukocytes, and caused increas ...

Mast cells with endocytic and autophagic vacuoles were observed in a biopsy from a lesion of urticaria pigmentosa. In several areas of the specimen the mast cells revealed the typical morphology of mast cells which have released low molecular weight mediators, but this phenomenon did not seem to be correlated morphologically to the phagocytic activity of the mast cells. Some mast cells contained g ...

Hemolysis induced by ultraviolet radiation as well as demethylchloretetracycline (DMCT) phototoxicity have been investigated in a model using human red blood cells. Total hemolysis for UV-B and UV-C was obtained with 8.3 and 1.9 J/cm2 respectively. DMCT was shown to have pronounced hemolytic properties causing 88% hemolysis at 50 micrograms/ml and 72 J/cm2 of UV-A. No increased hemolysis rate was ...

Intracutaneous injections of cholinergic agonists are usually employed for induction of local sweating. The possibility to apply a less painful skin prick technique as a sweat test was examined. Pricks were made on the forearm skin of 25 young men by puncturing the skin through drops of methacholine (MCH) and control saline solutions with lancets having a point length of 1 mm. The drops were kept ...

The ichthyotic skin in X-linked dominant chondrodysplasia punctata was investigated in a four-week-old baby and a fourteen-year-old girl. Histologically, the ichthyosiform erythroderma of the newborn and the ichthyosis of the older child presented as a retention hyperkeratosis with several distinctive features such as calcification of the keratotic follicular plugs, atrophy of the hair follicles a ...

Cutaneous T-cell lymphomas (CTCL) are neoplasias of mature T-cells and comprise Sezary syndrome, mycosis fungoides and some cases of lymphomatoid papulosis. Clinically this group of disorders differ from the more aggressive neoplasias of mature T-cells known as adult T-cell leukemia/lymphoma and T-cell lymphosarcoma leukemia which are associated with human T-cell leukemia virus (HTLV). We have fou ...

The annual incidence of IgA-positive dermatitis herpetiformis (DH) during the years 1976-1981 in Gothenburg, Sweden, a city with approximately 430000 inhabitants, was estimated prospectively. The mean annual incidence was 1.1 per 10(5) inhabitants. The prevalence of DH as at 31 December, 1981 was 22.9 per 10(5) inhabitants or 19.6 if patients in long-standing spontaneous remission were excluded. T ...

In preliminary clinical trials, a new retinoid, Arotinoid Ro 13-6298, was found highly effective in hyperproliferation and keratotic disorders. The aim of this investigation was to study the effect of Arotinoid on in vitro neonatal mouse keratinocyte proliferation and differentiation. Five doses of Arotinoid were tested. [3H]-Tdr labeling techniques and autoradiography were used to quantitate prol ...

Four patients with classic recalcitrant prurigo nodularis had symptomatic and physical responses to thalidomide with remissions. Three of the four patients had increased IgE levels that decreased during therapy. In two patients, short-term treatment (2 to 3 months) was not sufficient to produce remission, but retreatment was effective. Two patients had long-term remission with more than 6 months o ...

The brittle hair fibres from a case of osteogenesis imperfecta were studied by scanning and transmission electron microscopy. Normal hair fibres are extremely difficult to infect with T. mentagrophytes. As a tentative assay for biochemical defects of hair fibres, experimental dermatophytic infection of the hair with T. mentagrophytes was performed. The massive growth induced suggested that the exp ...

The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. Most of the infiltrating cells were seen to be mature T-lymphocytes with a suppressor/cytotoxic p ...

In 7 penicillamine-treated patients with generalized scleroderma zinc in serum, erythrocytes and granulocytes, alkaline phosphatase activity in serum and granulocytes, carbonic anhydrase activity in erythrocytes were examined. No significant difference was found between patient and control values, but granulocyte zinc strongly tended to be decreased (0.1 greater than p greater than 0.05). It is ou ...

The frequency and the severity of skin lesions were studied in patients with chronic venous insufficiency compared to the function of the muscle pump measured with plethysmography. The study showed that the frequency of skin symptoms parallels the muscle pump dysfunction. Measuring the ambulatory volume change on the calf level and the refilling time required for the normalisation of the calf volu ...

A patient with longstanding erythroderma and decreased sweat secretion due to the classical adult form of pityriasis rubra pilaris is described. The patient did not respond to oral megadoses of Vitamin A, even though a large increase of liver content of Vitamin A was demonstrated. Retinol-binding protein levels in serum of this patient and his relatives were normal. Danazol (Danatrol, Winthrop) th ...

Polymorphonuclear leucocyte chemotaxis was investigated in 6 patients with active dermatitis herpetiformis in the untreated state and when under control with Dapsone. Control studies were undertaken in 7 healthy volunteers. No significant difference in chemotaxis was demonstrated between the active, treated and control groups. Furthermore, when Dapsone in physiological concentrations was added sep ...

In order to investigate the effect of grenz rays on Langerhans´ cells in human epidermis, five healthy volunteers were treated with a single dose of 4 gray of grenz rays on a limited area of buttock skin. Biopsies were obtained before irradiation and from the irradiated site 30 min, 6 hours, 24 hours, 1 week and 3 weeks after X-ray therapy. There was a slight reduction after 30 min and a very pro ...

An anesthetic cream with an eutectic mixture of 5% lidocaine and 5% prilocaine has been tested on the skin of healthy subjects and patients with atopic dermatitis and generalized eczema. In healthy subjects a blanching was seen when the analgesia was complete after 30-60 min. In the dry skin and eczematous lesions of atopic dermatitis an application time of 5-15 min caused a blanching and a good a ...

Thirty patients with severe alopecia areata (A. A.) were treated with weekly applications of dinitrochlorobenzene (DNCB) in acetone solution. In only four patients regrowth of hair was complete and dense; sixteen patients experienced temporary results and in ten the treatment was a failure.

A 31-year-old woman developed typical clinical and laboratory signs of PCT at the end of her second pregnancy coincident with the summer season. She had elevated liver function values without history of alcoholism, hepatitis or chemical liver damage. She had taken oral contraceptive only before her first pregnancy which was normal. Her hormone analytic values including estrogens corresponded to no ...

No abstract available.

A 71-year-old man developed multiple subcutaneous nodules during Pseudomonas aeruginosa septicemia. The acute and simultaneous flare of inflammatory nodules in a septic patient appears to be rather specific in Pseudomonas infections. Histological vascular lesions are prominent in the subcutaneous nodules.

Pemphigoid vegetans in an 83-year-old man is reported. The histological and immunopathological findings were those of bullous pemphigoid rather than a variant of pemphigus.

A case of Hemophilus ducreyi infection clinically resembling granuloma inguinale is reported. Culture of the causative organism permitted a definitive diagnosis to be made. Combined treatment with tetracycline and sulphamethizole/trimethoprim rapidly cleared the infection.

No abstract available.