Content - Volume 64, Issue

The naturally occurring T lymphocytotoxic antibodies in patients with viral and related skin diseases were investigated and compared with those of systemic lupus erythematosus (SLE). The incidences of T lymphocytotoxic antibodies in exanthema suspected of viral infection, infectious mononucleosis, rubella and pityriasis rosea were 28%, 44%, 8% and 28% respectively. Sera from patients with herpes z ...

Thirty-one cases of primary cutaneous amyloidosis were studied by the immunoperoxidase technique (PAP method) employing anti-keratin antibodies. All specimens were examined using consecutive paraffin sections to confirm the correspondence between amyloid existing area and reactive sites. All of the sections examined were non-reactive in amyloid deposited sites whereas the epidermis always showed s ...

Two sensitive methods for the assessment of skin irritancy reactions to propylene glycol (PG) have been used: laser Doppler flowmetry in man for erythema and skin fold thickness measurements in man, guinea pigs and rabbits for edema. Single (open and occlusive) and repeated (open) exposures were used. Trafuril was used as positive control for the flowmetric studies. In man an increased blood flow ...

We have obtained spirochetes from Ixodes (I.) ricinus ticks collected in different areas in Stockholm where erythema chronicum migrans Afzelius (ECMA) cases are known to occur sporadically. Titers of antibody against spirochetal isolates, cultured in modified Kelly´s medium, from Swedish I. ricinus and American I. dammini ticks were determined by indirect immunofluorescence. With the I. ricinus r ...

Family and personal histories of atopy, total IgE level in serum, AB0 blood groups, trichophytin reactions, IgE RAST, IgG RAST and precipitating antibodies were investigated in patients with hereditary palmo-plantar keratoderma and dermatophytosis. 44% of the patients with dermatophytosis had a personal and/or family history of atopy and 67% a total IgE greater than 100 kU/ml. No significant diffe ...

Results are presented of the electron-microscopic examinations of fingernail clippings from 4 patients suffering from Mljet (Mal de Meleda) disease, of 3 obligate heterozygotes of this autosomal recessively inherited disease, as well as of 3 controls. In the nails of the diseased persons, significantly more osmiophilic material was found than in those of controls. In the nails of heterozygotes, th ...

Electron microscopic studies of biopsy specimens from a patient with lymphomatoid papulosis were performed. In the epidermis, infiltrating lymphoid cells, many of which had highly convoluted nuclei, were revealed to come into close contact to increased Langerhans´ cells but did not accumulate to form microabscesses. In the dermis, Langerhans´ cells with rather small numbers of Birbeck granules w ...

In a group of 93 patients with generalized bullous pemphigoid seen at the Mayo Clinic from 1970 to 1980, the frequency of concomitant malignancies did not appear to be higher than in the general population or in previously reported series from the Mayo Clinic. However, the subgroup with negative indirect immunofluorescent tests had an unexplained higher frequency of malignancy (4/28) than the subg ...

A series of 446 inpatients with drug eruption was studied to determine the causative agent and the clinical type. In over a half of the cases a provocation test confirmed the drug responsible for the reaction. Sulphonamides/trimethoprim and ampicillin/penicillin followed by phenazones were the most frequent agents causing eruptions. Sulphonamides were also the most common drugs inducing Lyell´s a ...

The effects of disulfiram, benzyl benzoate and DDT, all components of a common preparation (Tenutex) for the control of the head louse, were tested on louse eggs. A significant higher mortality of eggs was evident after treatment with (i) disulfiram, (ii) benzyl benzoate, (iii) these two substances mixed, and (iv) Tenutex. DDT in this concentration had no effect on the survival of the eggs. Long-t ...

Skin blood flow (SBF) was measured by the laser Doppler technique in lesional and clinically normal skin of 8 patients with psoriasis vulgaris during Goeckerman or beech tar therapy. The SBF measurements were performed before therapy and 1, 2, and 3-4 weeks after treatment was initiated. The results were compared to a clinical psoriasis index based on the objective assessment of infiltration, eryt ...

Epidermal Langerhans´ cell (LC) densities in vitiliginous skin (VS) and normal-appearing skin (NAS) were studied in 10 patients with common vitiligo. Monoclonal mouse anti human T6 antigen IgG1 and Ia antigen IgG2 (Ortho Pharmaceuticals) were used to characterize LC. Epidermal LC densities were calculated by means of an ocular square grid and expressed per 0.1 mm2. The results showed that LC dens ...

Four patients with so-called non-venereal sclerosing lymphangitis of the penis are reported. It was suggested that the affected vessels were veins by positively stained factor VIII related antigen with the unlabeled peroxidase-antiperoxidase method. If cord-like linear subcutaneous swelling observed in the coronary sulcus or dorsal region of the penile shaft originate from the vein, it seems corre ...

The assessment of zinc levels after oral administration of 100 mg of zinc gluconate was performed over a 72-hour period in 3 sectors: plasma, blister fluid and epidermis. The results show that zinc taken orally reaches the epidermis after 72 h and indicate the existence of an intermediary compartment between plasma and epidermis, represented by blister fluid, in which zinc concentration is 243.9 + ...

No abstract available.

23 patients suffering from psoriasis and being treated with beta-blocking agents were compared to a control group regarding psoriasis activity. Seven out of the 23 were affected by psoriasis after introduction of the beta-blocking drug. The mean age of onset was significantly higher (p less than 0.001) than that of the control group, which supports the provoking effects of beta-blocking agents. Re ...

A case of acrogeria, a premature aging syndrome with acral distribution, is reported in association with perforating elastoma and bony abnormalities.

Cutaneous manifestations in a case of Reiter´s disease were successfully treated by oral etretinate administration. The clinical and histopathological similarities between the skin lesions of Reiter´s disease and those of pustular psoriasis, which is known to respond to aromatic retinoids, suggested this treatment.

The clinical effect on acne vulgaris of topical treatment with meclocycline sulfosalicylate and systemic treatment with peroral tetracycline (500 mg daily) was compared in a double-blind study of 60 patients treated for 8 weeks. The reducing effect of Meclosorb cream and tetracycline tablets on the number of closed comedones, pustules, papules and cysts was marked and not significantly different. ...

In a controlled study, topical treatment with sulfur 10 per cent is shown to be equally effective as orally given tetracycline in the management of rosacea.

Treatment with 13-cis-retinoic acid during 12 weeks of a patient with multiple trichoepitheliomas and acne cystica et comedonica did not affect the number of trichoepitheliomas. The cystic lesions, most of them trichoepitheliomas with only a few non-inflammatory cystic acne lesions, were not affected by this treatment.

Treatment of large condylomata of the glans penis with a neodymium-YAG-laser is reported. The method offers certain advantages over more conventional means of therapy, but requires expensive equipment, experience and that precautionary measures be taken when the high-power laser is operated.

No abstract available.

No abstract available.