Content - Volume 63, Issue 1

The effect of limonene on citral sensitization and elicitation was studied by histological methods. Limo­nene decreases the intensity of citral sensitization and of the citral test. Possible interpretations of the influence of limonene are discussed; in particular, an effect of limonene at the macrophage leve! could explain the re­sults.

A group of 77 patients with atopic hand eczema were compared with 136 atopic dermatitis patients without hand manifestations. Age distribution was identical in the two groups, peaking at 25-39 years of age. Both groups were dominated by female patients. No differences existed between them with respect to atopic heredity, occurrence of other atopic manifestations, or distribution of serum IgE value ...

Four different theories have been presented to show how early melanosomes are formed and at what stage in melanosome formation melanization starts. In the present investigation the perikaryon of melanocytes have been studied and the longitudinal and the transverse diameter of stage I-IV melanosomes estimated before and after PUVA therapy in 5 patients. An increase in the longitudinal diameter of s ...

5-S-Cysteinyldopa concentrations in serum were studied in healthy individuals exposed to daily high-intensity UVA radiation. A marked increase in 5-S-cysteinyldopa was found after 3 days, and in some individuals concentrations were still higher after 7 to 10 days. The immediate pigment darkening (IPD) and delayed tanning (DT) were weak or absent at pressure sites, i.e. in skin with a low concentra ...

The status of the jejunal mucosa and of the intestinal absorptive capacity were investigated and related to the occurrence of antibodies against reticulin and gluten in 55 patients with dermatitis herpetiformis (DH), 28 on a normal, 11 on a gluten-reduced and 16 on a gluten-free diet. The mucosal status was characterized on the basis of histopathological findings and the numbers of intra-epithelia ...

Pruritic urticarial papules and plaques of preg­nancy (PUPPP) has been defined as an intensely pru­ritic cutaneous eruption occuring in the third trimester of pregnancy. 11 resolves spontaneously or at parturition. We present our experience with 15 cases of this new entity.

beta 1H globulin is a plasma protein which regulates the biologic activities of the major fragment of the 3rd complement component, C3b. The role of beta 1H globulin in pemphigus was investigated using immunofluorescence in the present study. Lesional skin biopsies from patients with confirmed pemphigus demonstrated in-vivo deposition of beta 1H in addition to C3 in all of four biopsies. Eight ser ...

Finger blood flow was measured continuously by a laser-Doppler flowmeter in normal subjects and in patients suffering from primary or secondary Raynaud´s phenomenon. In normals, skin areas with and without arteriovenous anastomoses could be differentiated. Blood flow in areas with shunt vessels decreased after a deep breath but not during venous stasis or the Valsalva maneuvre, while in other ski ...

27 patients suffering from either extensive alopecia areata (n = 5) or alopecia totalis (n = 22) were treated topically with diphencyprone, a new potent contact allergen. The duration of treatment ranged from 4 to 17 months. Unilateral induction of hair growth after unilateral treatment was observed in 23 patients. A continuous response after continuous treatment has been observed so far in 18 of ...

Penicillin concentration in serum and cerebrospinal fluid (CSF) were estimated in 19 syphilitic patients given three different regimens: Penicillin G, 10 MIU i.v. three times a day (3 patients); procaine penicillin, 600 000 IU i.m. (11 patients); and penicillin V, 1.2 MIU by mouth four times a day (5 patients). Intravenous administration of penicillin G resulted in a penicillin concentration in CS ...

Diastereomers of 5-S-cysteinyldopa formed from D-dopa and L-cysteine or from L-dopa and D-cysteine can be separated from 5-S-cysteinyldopa formed from L-dopa and L-cysteine by liquid chromatography. The diastereomers have a great potential as internal standards in the analysis of 5-S-cysteinyldopa. They can be used as reference substances in the differentiation of stereospecific enzymatic oxidatio ...

A patient suffering from recalcitrant pemphigoid developed rolled hairs after prolonged oral corticosteroid therapy. Consequently, we looked for rolled hairs in 100 out-patients, but none could be found. The rolled hairs were characterized by light and scanning electron microscopy.

Estrogen- and androgen receptor levels were investigated in the skin of 11 male and 4 female rosacea patients. No significant difference in receptor distribution or in receptor levels could be found between rosacea lesions and normal skin of the same patients. Moreover, hormone serum levels were in the normal range. Data from the present investigation suggest that rosacea formation is not governed ...

In 4 patients with lichen planus mucosae (l.p.m.) biopsies were taken from the involved and uninvolved buccal sides before treatment and from the affected side after a 3-week systemic therapy with aromatic retinoid (Ro 10-9359; 50 mg/die). After in vitro labelling with 3H-thymidine the epithelial cell proliferation was determined histo-autoradiographically. In atrophic lesions of l.p.m., increased ...

Comedolytic activity was assessed in acne patients by determining the reduction in facial microcomedones using the cyanoacrylate follicular biopsy technique. Microcomedones were counted in five-em squares after 8 to 12 weeks of treatment. Only salicylic acid and tretinoin among seven conventional anti-acne medications were found to possess comedolytic activity. The latter was the more effective.

Clinical symptoms of menopause were recorded in 27 females with systemic sclerosis, mean age 53.5 years (range 22-68). Five had regular menstruation, and 22 were in the postmenopause, 2 with climacterium praecox. Mean age at menopause was 47.8 years (range 30-59) among the 22 females, and 49.3 years (range 40-59) among the 20 females with a normal climacterium. Eleven had physiological subjective ...

Two brothers, born in 1944 and 1950, had been brought up in separate homes since 1951. In 1978 they were both afflicted with Beh?ßet´s syndrome. This condition is uncommon in Scandinavia, and there are no other known reports of familial cases from the Scandinavian countries. The etiology of the disease is obscure and controversial. In our two cases a hereditary disposition seems more probable th ...

A case is reported of scleroderma ´en coup de sabre´ in a 13-year-old girl with atrophy of the nasal part of the iris and loss of cilia on the upper eyelid. The lesions of the front and eye were located on precisely the same line. The line did not follow the innervation fields of the cranial, peripheral or autonomous nerves. Nor did it follow the tension lines of the skin (Langer), or underlying ...

A 12-year-old white boy presented with symmetrically appearing papular, nodular, comedo-like, highly itching lesions involving the skin on his ankles. They had first appeared 3 years earlier. Numerous cutaneous biopsies showed tumoral buds of basalioma cells associated with follicular structures, infundibular cysts and also hypertrophy and hyperplasia of sebaceous glands. To the best of our knowle ...

A case of juvenile xanthogranuloma in a female newborn infant is reported. Red-brown, flat, well-demarcated lesions were present at birth on her scalp, face and trunk. During the following year of observation the eruptions regressed slowly and spontaneously. Light and electron microscopy revealed histiocytes and Touton giant cells dominating the dermal cell infiltrate. The Touton cells contained b ...

A 41-year-old Vietnamese refugee was found to have tuberculoid leprosy. Dapsone treatment cleared her skin lesion, but did not remove the paraesthesia in the right ulnar nerve. Immunological investigations revealed a strongly positive lepromin test and a significant change in the ratio of T-y and T-mu lymphocytes in peripheral blood. The incidence of leprosy in Vietnamese refugees in Scandinavia i ...

White sponge nevus is a rare, benign, inherited disorder of the mucous membranes, affecting mainly the oral mucosa. A case is reported of white sponge nevus, which showed a definite improvement following penicillin administration.

During the 15-year period from 1965 to 1979 a total of 142 cases of chondrodermatitis nodularis chronica helicis were diagnosed. 32% were women, a higher proportion than in earlier materials. The treatment was principally curettage followed by electrocauterization. 78 patients were re-examined after an average lag of 7.1 years. The relapse rate was 31%. This simple surgical technique seems equal t ...

7 out of 10 patients with long-standing allergic contact dermatitis of their hands were successfully treated with short-wave ultraviolet light (UVB) and the contact dermatitis healed completely. To maintain this result they had to receive UVB therapy regularly once a week. The last 3 patients also showed improvement, but they had periods with vesiculation during the treatment. UVB treatment seems ...

The ichthyosis of seven patients with the Sj??gren-Larsson syndrome was treated with an aromatic retinoid, etretinate, during six months. Very good results were registered in six of the patients measured both as clinical improvement and as reduction in quantity of emollients needed. No unexpected side effects were noted.