Content - Volume 62, Issue 1

The effect of occlusion on epidermal morphology was studied at electron microscopic resolution. the morphological changes recorded were relatively mild, though conspicuous, and consisted in dilatation of the intercellular space, appearance of cytoplasmic vacuoles and an oedematous change in the dermis. Stereological analysis showed that the dilatation of the intercellular space had a biphasic time ...

The influence of PUVA treatment on junction A-cell nevi in psoriatic patients has been analysed. After long-term PUVA therapy the nevocytes display an obvious increase in melanosome synthesis. The melanosomes are clearly polymorphous, without any predominant configuration. The structural organization of the melanosomes is profoundly aberrant. Formation of autophagosomes is conspicuous. The cytopla ...

Skin biopsies from a patient suffering from lichen nitidus were studied by electron microscopy and immunofluorescence studies. Complete disintegration of the stratum basale in the central area of the lesion and signs of acantholysis in the border area were found. In the central part of the lesion the dermo-epidermal junction was severely damaged in most places. In the dermal infiltrate, macrophage ...

The morphology of the horny layer was utilized to determine the age distribution of corneocytes in early psoriatic lesions and in their vicinity. By using the age distribution the number of corneocyte layers found in any time interval could be obtained and expressed as the rate of corneocyte layers formed. Deposits if immunoglobulins G, M and A and C3 were also age-distributed in a similar way. In ...

Evidence has been obtained of deposition of complement component C1q in mast cells, by the immunofluorscence technique, using biopsy specimens from the scalp from 5 of 7 normal subjects and 14 of 17 patients with alopecia areata and also from skin lesions of 1 of 2 patients with urticaria pigmentosa studied. The fluorescence in mast cells was of a granular pattern in most instances. No deposition ...

The total number of circulating T lymphocytes in 47 patients with atopic dermatitis was a significantly lower than in 98 healthy persons. However, when the T lymphocytes were investigated for their affinity to sheep erythrocytes (E-rosette formation), no difference was found between patients and healthy persons, when using several different techniques varying in length of incubation of sheep eryth ...

The occurrence of nickel allergy and hand eczema has been investigated in a stratified sample (2 500) of the Danish female population by an interview technique. The incidence density (allergy intensity) has been estimated by standard maximum likelihood methods. The age-specific prevalence rates have been calculated by life table techniques. The incidence density has doubled in all age groups from ...

Thirty-seven healthy persons were studied in order to evaluate the influence of topical steroid application on tuberculin skin reactions. Four areas measuring 4 cm in diameter were each treated with 50 micrograms of hydrocortisone cream 1%, or 50% micrograms of halcinonide (Halog) cream 0.1%, or 50 micrograms of unguentum cetacei simplex (cold cream), or not treated. The creams were applied once d ...

Sixteen patients with mycosis fungoides (MF) were given either active transfer factor (TF) or heat-inactivated TF as additional therapy to topical nitrogen mustard or PUVA. The TF was prepared from non-selected healthy blood donors. The clinical evaluation after 2 years of therapy showed that among 8 patients treated with active TF, none went into complete remission of their disease 4 patients had ...

Eleven patients with delusions of infestation were treated with pimozide using a double-blind crossover technique. Ten out of 11 patients improved. The investigation showed significant relief of itch and delusions during pimozide treatment. Brief Psychiatric Rating Scale (BPRS) points decreased significantly. Adverse effects were few by 2 patients showed dose-related depressive reactions during tr ...

In this work, we observed that several vehicle components which are complex lipids inhibited the oxidation of arachidonic acid in the oxygen monitor assay. Inhibition of oxygen consumption in this assay, a relatively non-specific finding, may reflect inhibition of lipoxygenase and/or prostaglandin synthetase activity or possible sequestration of arachidonic acid. Theoretically, similar effects cou ...

Aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) (EC 2.5.1.18) activity were measured in human lymphocytes of peripheral blood from 8 patients with irritant or allergic contact dermatitis of the hands, and compared with data from a control group. Both AHH and GST activity was found to be significantly depressed in the allergic and irritant contact dermatitis subjects, as comp ...

A case of acral syringoma associated with the usual eruption on the lower eyelids was examined by light and electron microscopy for the first time. In the upper dermis there were a few ducts and cystic formation, while predominant atypical solid strands composed of tumor cells were often seen by light microscopy. Electron microscopy showed the formation of small ducts in the solid strands and nume ...

Electron microscopical observations were made in a case of solitary trichoepithelioma. Enlarged ERs were found in the tumor cells, showing a peculiar structure with fine granules and an electron-dense banded structure, about 50 nm wide respectively, lying at intervals of 250 nm. In addition to this structure, dense ovoid bodies, about 500 to 600 nm in diameter, were also observed.

One hundred patients with viral warts and 108 apparently healthy matched controls were typed for HLA-A and B antigens. No significant difference in the frequencies of antigens was revealed, which suggested that a possible genetic trend in warts is at least not related to A and B loci of the histocompatibility system.

Sixteen patients with papulovesicular, 6 with nodular and one with a Norwegian scabies were studied. Direct immunofluorescence (IF) examination revealed C3 deposits in the skin lesions of 13 of the 18 patients. Among them were all 6 cases with nodular scabies. C3 was found mostly in dermal vessel walls and 3 of the patients also showed IgM and 2 IgA deposits at the same site. No circulating immune ...

A 24-year-old female patient with congenital ichthyosiform erythroderma, deafness and vascularizing keratitis yet also examining normal sweating and tear production when tested is reported. This unique finding indicates that a certain subgroup of patients with this generalized ectodermal disturbance may benefit from treatment with the aromatic retinoids.

No abstract available.

Vaginal pain over a period of 3 years has been shown to be based on a vesiculo-bullous acantholytic disorder suggesting familial chronic benign pemphigus (Morbus Hailey-Hailey). Local applications of 5 ml 1% hydrocortisone-enterochinol cream resulted in an almost total regression of all the symptoms, including dyspareunia.

A patient with active, generalized morphoea was treated successfully with salazopyrine on two occasions. The first time the trunk was involved and most of the skin softened after the drug therapy was started. After salazopyrine was discontinued, morphoea developed in the thighs but recommencement of therapy resulted in complete resolution.

No abstract available.

No abstract available.

Kaposi´s varicelliform eruptions, or Eczema herpeticum, are the result of a herpes virus infection. This paper reports on a patient who was treated with parenteral infusion of a new anti-viral drug, adenine arabinoside (Vira-A), and transfer factor in an attempt to halt the spread and alleviate the severity of the disease. It is our opinion that adenine arabinoside can have a beneficial effect on ...

An 8-year-old girl with chronic mucocutaneous candidiasis was treated with Ketoconazole 100 mg daily for 6 weeks. Oral thrush disappeared after a week, while cutaneous lesions cleared within a month. Her nail dystrophy disappeared during the following months. Repeated cultures were negative for Candida albicans. The patient has remained in remission for an 8-month period. Our findings thus support ...

No abstract available.