Experimental treatment in atopic dermatitis: lmmunological background and preliminary results
H. Zachariae, K. Thestrup-Pedersen, H. Thulin, J. Thormann, T. Herlin, M. Cramers, J. Jensen, K. Kragballe, H. Afzelius, Overgaard Petersen
DOI: 10.2340/0001555592121127
Abstract
Experimental treatment in atopic dermatitis was undertaken with transfer factor, hyposensitization, or topical sodium chromoglycate. Both transfer factor and hyposensitization in open trials produced some clinical benefit. In both cases all patients could be controlled with medium strength topical steroids during therapy. In the latter case consumption of topical steroid was measured and found to decrease. lmprovement generally followed a decrease in serum lgE alter an initial rise. No significant changes in T-lymphocytes or serum lgE were observed during transfer factor therapy. Topically applied sodium chromoglycate 10% in white soft paraffin in a double-blind trial was no better than the placebo.
Significance
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