Kligman LH, Zheng P, Kligman AM.
DOI: 10.2340/0001555575205211

While assessing the protective effect of broad-spectrum sunscreens against chronic UVA radiation, we observed a paradoxical worsening of skin damage with one product. To further examine this finding, five proprietory broad-spectrum sunscreens were applied to albino hairless mice irradiated thrice weekly for 32 weeks with a UVASUN lamp (> 340 nm). Appropriate age-matched controls were included. After approximately 12 weeks, two sunscreens induced a marked dermatitis. Biopsies showed damage greatly exceeding that found in UVA-irradiated, unprotected controls. Histologically, elastic fibers were hyperplastic, coalescing into elastotic clumps. Glycosaminoglycans also increased. Collagen damage was notable since UVA alone does not induce a histologic change. Electron microscopy confirmed these findings. Two other sunscreens provided nearly complete protection. Against chronic UVB radiation, the two UVA photoirritating sunscreens provided substantial protection. Since the UVA sunfilter, oxybenzone, was the same in all sunscreens, we postulate that an irritating component of the vehicle was responsible for the UVA-induced photoirritation. The fifth sunscreen produced severe damage with UVB and UVA.