Sugiura H, Uehara M, Watanabe S.
DOI: 10.2340/0001555567166169

Immunohistochemically we examined six patients with ringworm which exhibited a well-marked erythematous edge and central resolution. To obtain a panoramic view of the immunopathological features of various evolutionary stages of skin lesion, we took a radial slice biopsy specimen extending from normal-appearing skin to central resolution. The actively involved edge had a moderate amount of dermal infiltrate of mononuclear cells which mostly consisted of T cells. The ratio of the helper T cells to suppressor T cells was 3.4. At the central resolution, the dermal infiltrate was mild, and the helper T/suppressor T ratio was 3.0. The well-marked erythematous edge showed a decrease of OKT6 positive Langerhans´ cells in the epidermis, while many OKT6 positive cells were present in the upper dermis. At the central resolution, however, OKT6 positive cells increased in number in the acanthotic epidermis.