Holland DB, Gowland G, Cunliffe WJ.
DOI: 10.2340/0001555565551553

Sub-populations of leucocytes, complement C3, CRP, alpha 2 macroglobulin and immunoglobulin levels were measured in the peripheral blood of 28 (14 male, 14 female) normal control subjects and 108 (53 male, 55 female) acne patients. Significantly increased levels of inflammatory mediators were found much earlier in female than in male acne patients. The female defence system would seem to be more competent at responding to the acne assault; may account for the milder forms of acne found in young women; and have relevance both in treatment and the design and interpretation of clinical trials.