Céline Phan, Nathalie Beneton, Juliette Delaunay, Ziad Reguiai, Claire Boulard, Anne-Claire Fougerousse, Elisa Cinotti, Marco Romanelli, Laure Mery-Bossard, Domitille Thomas-Beaulieu, Josiane Parier, François Maccari, Jean-Luc Perrot, Mireille Ruer-Mulard, Marie Bastien, Edouard Begon, Mahtab Samimi, Caroline Jacobzone, Nathalie Quiles-Tsimaratos, Vincent Descamps, Maud Steff, Paul Bilan, Annie Vermersch-Langlin, Mathilde Kemula, Emmanuelle Amazan, Ingrid Kupfer-Bessaguet, Anne-Caroline Cottencin, Francesca Prignano, Bulai Livideanu, Jeremy Gottlieb, Alain Beauchet, Emmanuel Mahé; for the Groupe d’Etudes Multicentriques (GEM) RESOPSO
DOI: 10.2340/00015555-3678

Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evalu­ated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.

Anti-interleukin-17 agents are biologic therapies that have recently been developed for the treatment of psoriasis. How­ever, data on their use for patients ≥ 65 years are limited A total of 114 elderly psoriatic patients who had received an anti-interleukin-17 agent were included in this study. Treatment was stopped in 28.9% of patients, mostly because of relapses, primary failures and adverse events. The 3 most frequently adverse events (n = 10) were injection site reactions, oral mycosis, and influenza-like illness. Regarding effectiveness, the treatment was considered efficient in 70% of patients, 6 months after treatment initiation. Anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis patients aged ≥ 65 years.