Wai Leong Kok, Yik Weng Yew, Tien Guan Steven Thng
DOI: 10.2340/00015555-3175

Atopic dermatitis (AD) is a systemic inflammatory disorder. However, the relationship between severity of AD and metabolic and atopic conditions is not well studied. The aim of this study was to elucidate the relationship between severity of AD and comorbidities, such as metabolic conditions (increased body mass index, hypertension, hyperlipidaemia, and type II diabetes mellitus) and other atopic manifestations (allergic rhinitis, asthma and food allergies). A retrospective population-based national study of a cohort of young adult males conscripted into military service in Singapore over a 5-year period was performed, utilizing military electronic medical records. A dose-dependent effect was found between the association of comorbidities and severity of AD. Metabolic and atopic conditions were significantly correlated with having moderate-to-severe AD. An association of metabolic and atopic conditions with severity of adult AD was found, which suggests that chronic severe AD may result in increased disease burden and morbidity.

- Associations between metabolic and atopic diseases with atopic dermatitis severity are not well described.
- Positive correlations were found between metabolic and atopic co-morbidites and an increasing severity of AD in our study.
- Management of metabolic and atopic co-morbidities, is important in the holistic management of adult AD.