Lina U. Ivert, Carl-Fredrik Wahlgren, Lena Ivert, Maria Lundqvist, Maria Bradley
DOI: 10.2340/00015555-3121

Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. We have described patient characteristics, including FLG mutations, atopic history and clinical effect of dupilumab. Nine of 10 developed eye-complications, most commonly conjunctivitis (in 7/10). Other adverse events were herpes simplex virus uveitis and varicella-zoster virus meningitis. Although our case series is small, we conclude that dupilumab is an effective treatment option in severe atopic dermatitis, but that the risk of adverse events from the eyes and recurrence of herpes virus infections should be kept in mind. Close collaboration with an ophthalmologist is recommended, especially among patients with severe, long-lasting atopic dermatitis and/or previous eye disease.

Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated impressive clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis was reported in a minority of patients. We describe 10 patients treated with dupilumab where eye complications where common, suggesting the importance of close collaboration with an ophthalmologist. This is especially warranted among patients with severe, long-lasting atopic dermatitis and/or previous eye disease.