Content » Vol 89, Issue 6

Investigative Report

Detection of Human Herpesvirus 8 in the Skin of Patients with Pityriasis Rosea

Anestis Prantsidis, Dimitrios Rigopoulos, Georgios Papatheodorou, Panayiotis Menounos, StamatisGregoriou, Ifigeneia Alexiou-Mousatou and Andreas Katsambas
DOI: 10.2340/00015555-0703

Abstract

Pityriasis rosea is an acute self-limiting dermatosis with clinical and epidemiological features that suggest viral involvement. The aim of this study was to investigate a possible association between pityriasis rosea and human herpesvirus 8 (HHV-8). Lesional skin tissue was obtained from 34 Kaposi’s sarcoma-negative, immunocompetent patients with typical acute phase pityriasis rosea. Nested polymerase chain reaction with specific primer for HHV-8 DNA sequences was performed and all positive results were confirmed by sequencing. Seven out of 34 lesional skin specimens (20.5%) were found to be positive for the HHV-8 genome. All the positive samples were confirmed by DNA sequencing. We conclude that, in some cases, HHV-8 is implicated the pathogenesis of pityriasis rosea.

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