- List articles in this issue
Detection of Human Herpesvirus 8 in the Skin of Patients with Pityriasis Rosea
Pityriasis rosea is an acute self-limiting dermatosis with clinical and epidemiological features that suggest viral involvement. The aim of this study was to investigate a possible association between pityriasis rosea and human herpesvirus 8 (HHV-8). Lesional skin tissue was obtained from 34 Kaposi’s sarcoma-negative, immunocompetent patients with typical acute phase pityriasis rosea. Nested polymerase chain reaction with specific primer for HHV-8 DNA sequences was performed and all positive results were confirmed by sequencing. Seven out of 34 lesional skin specimens (20.5%) were found to be positive for the HHV-8 genome. All the positive samples were confirmed by DNA sequencing. We conclude that, in some cases, HHV-8 is implicated the pathogenesis of pityriasis rosea.
Anestis Prantsidis, Dimitrios Rigopoulos, Georgios Papatheodorou, Panayiotis Menounos, StamatisGregoriou, Ifigeneia Alexiou-Mousatou and Andreas Katsambas
Allen RA, Janniger CK, Schwartz RA. Pityriasis rosea. Cutis 1995; 56: 198–202.
Blauvelt A. Skin diseases associated with human herpesvirus 6, 7 and 8 infection. J Invest Dermatol Symp Proc 2001; 6: 197–202.
Drago F, Ranieri E, Malaguti F, Battifoglio ML, Losi E, Rebora A. Human herpesvirus 7 in patients with pityriasis rosea. Dermatology 1997; 195: 374–378.
Drago F, Ranieri E, Malaguti F, Losi E, Rebora A. Human herpesvirus 7 in pityriasis rosea. Lancet 1997; 349: 1367–1368.
Kempf W, Adams V, Kleinhans M. Pityriasis rosea is not associated with human herpesvirus 7. Arch Dermatol 1999; 135: 1070–1072.
Watanabe T, Kamamura T, Jacob SE, Aquilino E, Orenstein JM, Black JB, et al. Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol 2002; 119: 793–797.
Broccolo F, Drago F, Careddu AM, Foglieni C, Turbino L, Cocuzza CE, et al. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. J Invest Dermatol 2005; 124: 1234–1240.
Watanabe T, Sugaya M, Nakamura K, Tamaki K. Human herpesvirus 7 and pityriasis rosea (correspondence). J Invest Dermatol 1999; 113: 288–289.
Drago F, Rebora A. Pityriasis rosea: one virus, two viruses, more viruses? (correspondence). Br J Dermatol 2001; 144: 1086–1099.
Kosuge H, Tanaka-Taya K, Miyoshi H, Amo K, Harada R, Ebihara T, et al. Epidemiological study of human human herpesvirus 6 and human human herpesvirus 7 in pityriasis rosea. Br J Dermatol 2000; 143: 795–798.
Chuh AAT, Chiu SS, Peiris JS. Human herpesvirus 6 and 7 DNA in peripheral blood leucocytes and plasma in patients with pityriasis rosea by polymerase chain reaction: a prospective case control study. Acta Derm Venereol 2001; 81: 289–290.
Karabulut AA, Kocak M, Yilmaz N, Eksioglu M. Detection of human herpesvirus 7 in pityriasis rosea by nested PCR. Int J Dermatol 2002; 41: 563–567.
Drago F, Ranieri E, Rebora A. Pityriasis rosea and herpesvirus 7. Action or interaction? Dermatology 1998; 197: 275.
Drago F, Vecchio F, Rebora A. Use of high-dose acyclovir in pityriasis rosea. J Am Acad Dermatol 2006; 54: 82–85.
Ablashi DV, Chatlynne LG, Whitman Jr. JE, Cesarman E. Spectrum of Kaposi sarcoma-associated herpesvirus, or human herpesvirus 8, diseases. Clin Microbiol Rev 2002; 15: 439–464.
Plancoulaine S, Abel L, Gessain A. Epidemiology of human herpes virus 8 (HHV-8) or the herpes virus associated with Kaposi’s sarcoma. Pathol Biol 2002; 50: 496–502.
Sarid R, Olsen SJ, Moore PS. Kaposi’s sarcoma-associated herpesvirus: epidemiology, virology, and molecular biology. Adv Virus Res 1999; 52: 139–232.
Zavitsanou A, Sypsa V, Petrodaskalaki M, Kalapothaki V, Whitby D, Hatzakis A. Human herpesvirus 8 (HHV-8) infection in healthy urban employees from Greece: Seroprevalence and associated factors. J Med Virol 2007; 79: 591–596.
Zavos G, Gazouli M, Papaconstantinou I, Lukas JC, Zografidis A, Kostakis A, et al. Prevalence of human herpesvirus 8 DNA sequences in human immunodeficiency virus-negative individuals without Kaposi’s sarcoma in Greece. In Vivo 2005; 19: 729–732.
Stratigos JD, Katoulis AC, Stavrianeas NG. An overview of classic Kaposi’s sarcoma in Greece. Adv Exp Med Biol 1999; 455: 503–506.
Cerimele F, Curreli F, Ely S, Friedman-Kien AE, Cesarman E, Flore O. Kaposi’s sarcoma-associated herpesvirus can productively infect primary human keratinocytes and alter their growth properties. J Virol 2001; 75: 2435–2443.
Flore O, Rafii S, Ely SJ, O’Leary JJ, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi’s sarcoma-associated herpesvirus. Nature 1998; 394: 588–592.
Chuh AAT, Chan PKS, Lee A. The detection of human herpesvirus-8 DNA in plasma and peripheral blood mononuclear cells in adult patients with pityriasis rosea by polymerase chain reaction. J Eur Acad Derm Venereol 2006; 20: 667–671.
There are no related articles.
Share with your friends
There is no supplementary for this article.
Volume 89, Issue 6
View at PubMed